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January 1964, Vol 107, No. 1 >
Article | January 1964

Hypertrophic Osteoarthropathy in Cystic Fibrosis FREE

HERMAN GROSSMAN, MD; CAROLYN R. DENNING, MD; DAVID H. BAKER, MD
[+] Author Affiliations

Received for publication Aug 5, 1963.


Am J Dis Child. 1964;107(1):1-6. doi:10.1001/archpedi.1964.02080060003001.
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References
Comments

Pulmonary hypertrophic osteoarthropathy (PHOA) in cystic fibrosis has not been previously described in the English language, except for one patient mentioned briefly by Caffey.1 It is our purpose to present two patients with cystic fibrosis and symptomatic PHOA, and to give a preliminary report on the incidence of asymptomatic PHOA in cystic fibrosis. A brief discussion as to possible etiological factors of PHOA will also be given.

PHOA is extremely rare in children; only ten cases were reported in the American and British literature up to 19602; since then none has been reported. Clubbing is a common finding in cyanotic congenital heart disease and bronchiectasis, but PHOA is rarely associated with the former3 and only occasionally with the latter. Clubbing and PHOA are felt by many to have a similar pathogenesis, and the former represents a more advanced state of the process.2,4,5 While it is true

REFERENCES

1 +
Caffey, J.: Pediatric X-Ray Diagnosis , Chicago: The Yearbook Medical Publishers, Inc., 1961;, p 1125.
2 +
Medlin, V. L.:  Hypertrophic Osteoarthropathy in Children , Radiology 74:414, 1960;.
3 +
Trever, R. W.:  Hypertrophic Osteoarthropathy in Association With Congenital Heart Disease , Ann Intern Med 48:650, 1958;.
4 +
Ginsburg, J.:  Observations on the Peripheral Circulation in Hypertrophic Pulmonary Osteoarthropathies , Quart J Med 27:335, 1958;.
5 +
Mendlowitz, M.:  Clubbing and Hypertrophic Osteoarthropathy , Medicine 21:269, 1942;.
6 +
Holling, H. E., and Brodey, R.:  Pulmonary Hypertrophic Osteoarthropathy , JAMA 178:977, 1961;.
7 +
Cudowica, L., and Wraith, D. G.:  An Evaluation of the Clinical Significance of Clubbing in Common Lung Disorders , Brit J Tuberc 51:14, 1957;.
8 +
Holling, H. E.; Brody, R. S.; and Boland, H. D.:  Pulmonary Hypertrophic Osteoarthropathy , Lancet 2:1269, 1961;.
9 +
Coury, D.:  Hippocratic Fingers and Hypertrophic Osteoarthropathy , Brit J Dis Chest 54:202, 1960;.
10 +
Gottlieb, C.; Sharlin, H. S.; and Field, H.:  Hypertrophic Pulmonary Osteoarthropathy , J Pediat 30:462, 1947;.
11 +
Ray E. S.:  Pulmonary Osteoarthropathy , Amer Practit 10:1911, 1959;.
12 +
Gall, E. A.; Bennett, G. A.; and Bauer, W.:  Generalized Hypertrophic Osteoarthropathy , Amer J Path 27:349, 1951;.
13 +
Logan, J. S.; Marshall, R. J.; Shepherd, J. T.; and Whelan, R. F.:  Changes in the Hand Circulation in a Case of Pulmonary Osteoarthropathy , Irish J Med Sci Series 6 , No. 339:127, 1954;.
14 +
Hall, G. H.:  The Cause of Digital Clubbing , Lancet 1:750, 1959;.
15 +
Stein, H., and Stein, S.:  Digital Clubbing in Cirrhosis of the Liver , Lancet 2:999, 1961;.
16 +
Flavell, G. R.:  Reversal of Pulmonary Hypertrophic Osteoarthropathy in Vagotomy , Lancet 1:260, 1956;.
17 +
Hausen, J. L.:  Bronchial Carcinoma Presenting as Arthralgia , Acta Med Scand 142 ( (suppl 266) ) 467, 1952;.
18 +
Huchstep, R. L., and Bodkin, P. E.:  Vagotomy in Hypertrophic Pulmonary Osteoarthropathy Associated With Bronchial Carcinoma , Lancet 2:343, 1958;.
19 +
Skinner, F. F.:  The Treatment of Chronic Hypertrophic Pulmonary Osteoarthropathy by Surgery of the Chest , Dis Chest 41:571, 1962;.
20 +
Diner, W. C.:  Hypertrophic Osteoarthropathy: Relief of Symptoms by Vagotomy , JAMA 181:555, 1962;.
21 +
Andersen, D. H.:  Cystic Fibrosis of the Pancreas , J Chronic Dis 7:58, 1958;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Caffey, J.: Pediatric X-Ray Diagnosis , Chicago: The Yearbook Medical Publishers, Inc., 1961;, p 1125.
2 +
Medlin, V. L.:  Hypertrophic Osteoarthropathy in Children , Radiology 74:414, 1960;.
3 +
Trever, R. W.:  Hypertrophic Osteoarthropathy in Association With Congenital Heart Disease , Ann Intern Med 48:650, 1958;.
4 +
Ginsburg, J.:  Observations on the Peripheral Circulation in Hypertrophic Pulmonary Osteoarthropathies , Quart J Med 27:335, 1958;.
5 +
Mendlowitz, M.:  Clubbing and Hypertrophic Osteoarthropathy , Medicine 21:269, 1942;.
6 +
Holling, H. E., and Brodey, R.:  Pulmonary Hypertrophic Osteoarthropathy , JAMA 178:977, 1961;.
7 +
Cudowica, L., and Wraith, D. G.:  An Evaluation of the Clinical Significance of Clubbing in Common Lung Disorders , Brit J Tuberc 51:14, 1957;.
8 +
Holling, H. E.; Brody, R. S.; and Boland, H. D.:  Pulmonary Hypertrophic Osteoarthropathy , Lancet 2:1269, 1961;.
9 +
Coury, D.:  Hippocratic Fingers and Hypertrophic Osteoarthropathy , Brit J Dis Chest 54:202, 1960;.
10 +
Gottlieb, C.; Sharlin, H. S.; and Field, H.:  Hypertrophic Pulmonary Osteoarthropathy , J Pediat 30:462, 1947;.
11 +
Ray E. S.:  Pulmonary Osteoarthropathy , Amer Practit 10:1911, 1959;.
12 +
Gall, E. A.; Bennett, G. A.; and Bauer, W.:  Generalized Hypertrophic Osteoarthropathy , Amer J Path 27:349, 1951;.
13 +
Logan, J. S.; Marshall, R. J.; Shepherd, J. T.; and Whelan, R. F.:  Changes in the Hand Circulation in a Case of Pulmonary Osteoarthropathy , Irish J Med Sci Series 6 , No. 339:127, 1954;.
14 +
Hall, G. H.:  The Cause of Digital Clubbing , Lancet 1:750, 1959;.
15 +
Stein, H., and Stein, S.:  Digital Clubbing in Cirrhosis of the Liver , Lancet 2:999, 1961;.
16 +
Flavell, G. R.:  Reversal of Pulmonary Hypertrophic Osteoarthropathy in Vagotomy , Lancet 1:260, 1956;.
17 +
Hausen, J. L.:  Bronchial Carcinoma Presenting as Arthralgia , Acta Med Scand 142 ( (suppl 266) ) 467, 1952;.
18 +
Huchstep, R. L., and Bodkin, P. E.:  Vagotomy in Hypertrophic Pulmonary Osteoarthropathy Associated With Bronchial Carcinoma , Lancet 2:343, 1958;.
19 +
Skinner, F. F.:  The Treatment of Chronic Hypertrophic Pulmonary Osteoarthropathy by Surgery of the Chest , Dis Chest 41:571, 1962;.
20 +
Diner, W. C.:  Hypertrophic Osteoarthropathy: Relief of Symptoms by Vagotomy , JAMA 181:555, 1962;.
21 +
Andersen, D. H.:  Cystic Fibrosis of the Pancreas , J Chronic Dis 7:58, 1958;.

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