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Margin of Safety

Am J Dis Child. 1963;106(6):642. doi:10.1001/archpedi.1963.02080050644022.
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This book is a compendium of science, philosophy, politics, the power of press publicity, and the opinions of the author regarding the interactions of these factors on the development of preventive medicine in general and on the fight to eradicate infantile paralysis in particular. The first part of the volume beginning with the story of Jenner and smallpox vaccination is at once delightful and thought provoking. Part two may be said to embrace an account of the National Foundation for Infantile Paralysis, its March of Dimes, and its Basil O'Connor. The account tells of the great discovery by John Enders and his colleagues of a method of growing the virus of poliomyelitis in tissue culture and of utilization of the method by Jonas Salk to produce a formaldehyde-killed-virus vaccine against the disease. One captures again the fanfare of the times and the temporarily sobering influence of the Cutter disaster. Only


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