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Paternal Transmission of a 15/21 Translocation

ROBERT L. TIPS, MD; GEORGE S. SMITH, MD; DONALD L. MEYER, BS
Am J Dis Child. 1963;106(6):630-635. doi:10.1001/archpedi.1963.02080050632016.
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Phenotypically normal male carriers of the 15/21 chromosome translocation mainly produce carrier offspring, rather than normal children or children with the 15/21 (21,21) Down's disorder.1,2 Our report details the family of a mongoloid child with 15/21 translocation whose father's leukocytes demonstrate mosaic karyotypes; ie, some normal karyograms, some with balanced 15/21 polymorphism, and some with a multiplicity of other chromosomal abnormalities. The father is the survivor of 3½ years' internment in German concentration camps during World War II.

Materials and Methods  The patient is a four-year-old female with the typical appearance of mongolism; flat occiput, epicanthal folds, flat nasal bridge, Brushfield spots, high arched palate, large furrowed tongue, fissured lips, small ear lobes, short neck, crooked little fingers with a single interphalangeal joint, simian lines, short broad hands, diastasis recti, short broad feet, and first and second toe cleft.Dermatoglyphic analysis demonstrated a markedly elevated T1 triradius, hypothenar

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