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TETRACYCLINE SPLENOMEGALY IN YOUNG RABBITS

KITTY LITTLE, MA, D Phil; THOMAS EDGINGTON, MD
Am J Dis Child. 1963;106(5):521-522. doi:10.1001/archpedi.1963.02080050523025.
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To the Editor: The articles by Drs. Yadav et al in the March, 1963, (105:253) and Drs. Cohlan et al in the May, 1963, (105:453) issues of the American Journal of Diseases of Children are yet additional timely reminders of the possible toxic side effects of the commonly used tetracycline drugs. Increased awareness of occasional undesirable effects has prompted the inclusion of tetracyclines among the drugs discussed in the session on "Influence of Drugs on the Human Foetus and Newborn Infant" at the 1963 Annual Meeting of the British Medical Association (July 9-18).

The tetracycline group of drugs are very widely used and are generally considered to be without harmful physiologic side effects when administered in doses that are clinically efficacious for control of bacterial infections (10-25 mg/kg orally, 10-20 mg/kg parenterally). Not infrequently, however, they are used in doses greater than the maximal recommended therapeutic dose (eg, 50 mg/kg

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