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Serum Transcortin Levels in Acute Leukemia

FRANCES R. BEIER, MD; M. EUGENE LAHEY, MD; DOUGLAS C. HEINER, MD
Am J Dis Child. 1963;106(4):381-387. doi:10.1001/archpedi.1963.02080050383007.
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The existence in human plasma of a corticosteroid-binding protein was described by Daughaday in 19561 and given the name "transcortin" by Slaunwhite and Sandberg.2 Since then, transcortin has been the subject of extensive investigation,3-12 and several reviews summarize the properties and function of this protein.13-21 The concentration of transcortin in serum or plasma may be determined indirectly through its corticosteroid-binding properties by equilibrium dialysis,5 by measuring the in vitro distribution of C14-cortisol between plasma and red blood cells,22 or by gel filtration.23,30 It has been shown that transcortin has a high affinity for cortisol, so that when the plasma cortisol concentration is approximately 20μg to 30μg per 100 ml, the binding sites of this protein are virtually saturated.11 Seal and Doe have described a method for the isolation and purification of transcortin from normal plasma and from plasma of diethylstilbesterol-treated

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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