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Female Pseudohermaphroditism and Renal Anomalies

ROBERT C. FRANKS, M.D.; ROBERT NORTHCUTT, M.D.
Am J Dis Child. 1963;105(5):490-496. doi:10.1001/archpedi.1963.02080040492012.
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Introduction  "Somewhere in the no-man's-land between endocrinology, morphology, and genetics lie the hermaphroditic anomalies." 1 Since this statement by Perloff et al. in 1953, knowledge of the etiology and pathogenesis of hermaphroditic anomalies has markedly increased. The number of classifications of such anomalies, according to morphological and functional criteria, attests to the fact that much remains to be learned.The purposes of this report are to present a case report and discuss an abnormality for which there is no readily discernible endocrine or genetic mechanism.

Report of a Case  A white female was admitted to Vanderbilt Hospital at 3½ years of age in September, 1960. The mother was 32 years of age, the father 35, and both were well. There were 2 older male siblings who were considered normal. Four months prior to the patient's conception, the mother had a spontaneous abortion at about 8 weeks' gestation. The remainder of

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