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Renal Osteodystrophy in Two Siblings

Am J Dis Child. 1963;105(5):478-486. doi:10.1001/archpedi.1963.02080040480010.
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Recently we observed chronic renal disease with osteodystrophy occurring in two siblings, a boy and a girl. We studied the metabolism of calcium and phosphorus in these children in our metabolic unit before and during therapy with vitamin D. In this report we shall present the clinical findings and the metabolic balance data in this possibly familial metabolic derangement.

Report of Cases  Case 1.—A 13-year-old boy was seen at the Mayo Clinic in June, 1961, because of knock-knee, tiredness, and pain in the legs. To the parents' recollection this boy had been well until January, 1961, when his father noted that his son had difficulty keeping up with other children while playing basketball.Physical examination revealed a height of 55½ in (140.5 cm) and a weight of 69¼ lb (31.5 kg), both of which were below the third percentile for the patient's age. His blood pressure was 120 mm of


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