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Human Growth Hormone in Dwarfism Since Birth

DAGFINN AARSKOG, M.D.
Am J Dis Child. 1963;105(4):368-374. doi:10.1001/archpedi.1963.02080040370008.
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In the few years which have passed since the introduction of human growth hormone (HGH) in clinical research, it has been well documented that the hormone promotes growth in pituitary dwarfs.1-8 This effect has so far not been found in primordial dwarfs1,2 or in normal children9 when treated with HGH in doses that will produce growth in pituitary dwarfs. Growth response to HGH has been reported in several children in whom no endocrine abnormality could be demonstrated. It has, however, been suggested that these children may have been deficient in growth hormone.5,8

It is the purpose of this paper to report the results of HGH treatment in a 2½-year-old boy with retarded bone age, who manifested dwarfish growth from birth. Although physical and laboratory findings did not suggest panhypopituitarism, his response to HGH treatment was both qualitatively and quantitatively similar to that encountered in pituitary dwarfs.

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