0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Septicemic Adrenal Hemorrhage

WILLIAM MARGARETTEN, M.D.; HISAYO NAKAI, M.D.; BENJAMIN H. LANDING, M.D.
Am J Dis Child. 1963;105(4):346-351. doi:10.1001/archpedi.1963.02080040348004.
Text Size: A A A
Published online

Although adrenal hemorrhage is well known to occur in approximately 3% to 4% of persons infected with Neisseria meningitidis,1 it is not so well appreciated that the lesion may occur with infection due to other organisms.2,3 Adrenal hemorrhage, itself, was formerly considered the cause of circulatory collapse and death in fulminant meningococcemia, and replacement therapy with adrenal cortical steroids was advocated on this basis.4,5 Treatment of acute meningococcemia with corticotropin and steroids, however, has recently been questioned, since adrenal insufficiency has never been demonstrated in such patients and their various thrombotic lesions, including adrenal hemorrhage, may be due to the generalized Shwartzman phenomenon, which is known to be potentiated by adrenal steroids.6-8 The present report is an investigation of the pathogenesis of adrenal hemorrhage associated with infections due to bacteria other than N. meningitidis.

Material and Observations  The necropsy reports of patients dying at the Cincinnati

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();