Scleredema adultorum, Buschke, is a rare connective tissue disorder which affects all ages, including children. The disease is adequately described in American texts of dermatology, internal medicine, and pathology; but the American pediatric literature is strangely silent on the subject. Pediatric texts do not even acknowledge the existence of the disorder, and the single case described in an American pediatric journal1 was published 25 years ago. The practical importance of knowing scleredema adultorum rests on the fact that the disease is benign and self-limited but is easily mistaken for conditions which carry a poor prognosis and tend to be progressive. This error, made by myself and many others, has caused much avoidable unhappiness. For this reason it seemed appropriate to report 2 new pediatric cases, to outline the salient features of the disease in children as gathered from the world literature, and to discuss possible pathogenic mechanisms.