Plasma Hemoglobin Concentration in Umbilical Cord Blood FREE

ROLF L. ANDERSON, M.D.; HUGH CHAPLIN, M.D.

Submitted for publication Jan. 2, 1962.

Presented in part at the meeting of the Midwestern Section of the American Federation for Clinical Research, Chicago, Nov. 2, 1961.

This investigation was supported by Research Grant C-2918 (C4) from the National Cancer Institute.

Am J Dis Child. 1963;105(1):19-26. doi:10.1001/archpedi.1963.02080040021004.

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ABSTRACT

ABSTRACT | REFERENCES

The concentration of hemoglobin in the plasma of normal human subjects has recently been reexamined in our laboratory, employing modified methods for blood sampling and for hemoglobin measurement.^1,2 Study of 25 ambulatory adults revealed a mean value for plasma hemoglobin concentration (PHgbC) of 0.31 mg. per 100 ml., with a range of 0.16 to 0.58 mg. per 100 ml.

As part of a broad study of PHgbC in normal subjects, preliminary observations were made on blood samples obtained from 6 women at the time of parturition and from the placental segment of the umbilical vein immediately after separation of the newborn infants. Although PHgbC was within the normal range for the 6 maternal samples, all of the umbilical vein samples yielded elevated values, half of them in the range 10 to 20 times the mean value for normal adults. Since to our knowledge this phenomenon had not been previously

REFERENCES

ABSTRACT | REFERENCES

Hanks, G. E.; Cassell, M.; Ray, R. N., and Chaplin, H., Jr.: Further Modification of the Benzidine Method for Measurement of Hemoglobin in Plasma , J. Lab. Clin. Med. 56:486-498, 1960;.

Chaplin, H., Jr.; Cassell, M., and Hanks, G. E.: The Stability of the Plasma Hemoglobin Level in the Normal Human Subject , J. Lab. Clin. Med. 57:612-619, 1961;.

Malloy, H. T., and Evelyn, K. A.: The Determination of Bilirubin with the Photoelectric Colorimeter , J. Biol. Chem. 119:481-490, 1937;.

Lathem, W., and Worley, W. E.: The Distribution of Extracorpuscular Hemoglobin in Circulating Plasma , J. Clin. Invest. 38:474-483, 1959;.

Tuttle, A. H.: Demonstration of Hemoglobin-Reactive Substance in Human Serum , Science 121: 701-702, 1955;.

Garby, L., and Noyes, W. D.: Studies on Hemoglobin Metabolism: I. The Kinetic Properties of the Plasma Hemoglobin Pool in Normal Man , J. Clin. Invest. 38:1479-1483, 1959;.

Cassell, M., and Chaplin, H., Jr.: Changes in the Recipient's Plasma Hemoglobin Concentration After Transfusion with Stored Blood , Transfusion 1:23-31, 1961;.

Laurell, C. B., and Nyman, M.: Studies on the Serum Haptoglobin Level in Hemoglobinemia and Its Influence on Renal Excretion of Hemoglobin , Blood 12:493-506, 1957;.

Nosslin, B. F., and Nyman, M.: Haptoglobin Determination in Diagnosis of Haemolytic Diseases , Lancet 1:1000-1001, 1958;.

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