We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Serologic Response to a Fifth Injection of Salk Vaccine

Am J Dis Child. 1962;104(4):397-400. doi:10.1001/archpedi.1962.02080030399013.
Text Size: A A A
Published online


Introduction  Recommendations concerning the necessity of a fifth injection of Salk vaccine must be based on information available about the immune status of individuals who have received 4 injections of Salk vaccine. The best available method to determine susceptibility that does not involve exposure to the virus is to measure the concentration in the serum of neutralizing antibodies against the 3 types of poliovirus. Further, the antibody response which occurs after a booster injection may give more information than measurement of serum antibodies without antigenic stimulation. This report describes the neutralizing antibody titers in the sera of school-age children before and after a fifth injection of Salk vaccine.

Materials and Methods  One hundred and one normal children living in a Children's Home were selected for a fifth injection of Salk vaccine in May, 1961. The dates of all previous injections of Salk vaccine were known. Three or more years had


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.