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The Role of Allergy in Viral Respiratory Tract Infections FREE

GERALDINE L. FREEMAN, M.D.; RICHARD H. TODD, M.D.
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Submitted for publication Nov. 2, 1961.


Am J Dis Child. 1962;104(4):330-334. doi:10.1001/archpedi.1962.02080030332002.
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Introduction  The exact interrelation of respiratory infections and allergy has been in dispute for years.1-5 Whether such illnesses as colds, bronchitis, and pneumonia are "trigger" mechanisms6 to the asthmatic attack or act by aggravating allergic reactions already in progress,7 or whether infectious agents "sensitize" the bronchial mucosa remains unsettled.1 The variety of terms that combine allergic and infectious connotations that are used to describe respiratory infections in the allergic individual—"intrinsic asthma," "asthmatic bronchitis," "infectious asthma," "asthmatoid bronchitis"—reveals the debatable status of this problem.6 Clarification of this question is made difficult by the lack of viral diagnostic studies in such cases and is further complicated by the uncertainty in distinguishing clinically between respiratory tract infection and allergic coryza.2,6This study attempted to determine whether the wheezing which occurred in children with viral respiratory tract illness was associated with an allergic diathesis in these children. The

REFERENCES

Rackemann, F. M.; Ratner, B., and Sulzberger, M. B.:  Round Table Discussion on Allergy in Children , J. Pediat. 9:808, 1936;.
Feinberg, S. M.: Allergy in Practice , Chicago, Year Book Medical Publishers, Inc., 1946;, pp. 88-90.
Cooke, R. A.: Allergy in Theory and Practice , Philadelphia, W. B. Saunders Company, 1947;, pp. 130-131.
Danilović, V.:  Le Role des infections des bronches dans l'asthme , Acta Allerg. (Kbh.) 14: 122, 1959;.
Feingold, B. F.:  Infection in Bronchial Allergic Disease , Pediat. Clin. N. Amer. 6:709, 1959;.
Tuft, L.:  Bronchial Asthma: A Critical Review , J. Allergy 17:27, 1946;.
Feingold, B. F.:  The Influence of Acute Infection upon the Course of Allergy in Children , J. Pediat. 34:545, 1949;.
Chanock, R. M., et al.:  Respiratory Syncytial Virus: I. Virus Recovery and Other Observations During 1960 Outbreak of Bronchiolitis, Pneumonia, and Minor Respiratory Diseases in Children , J.A. M.A. 176:647, 1961;.
Parrott, R. H., et al.:  Respiratory Syncytial Virus: II. Serologic Studies over a 34-Month Period of Children with Bronchiolitis, Pneumonia, and Minor Respiratory Diseases , J.A.M.A. 176: 653, 1961;.
Parrott, R. H.:  Newly Isolated Viruses in Respiratory Disease , Pediatrics 20:1066, 1957;.
Parrott, R. H., et al.:  Clinical Features of Infection with Hemadsorption Viruses , New Engl. J. Med. 260:731, 1959;.
Parrott, R. H.: Personal communication to the authors.
Chanock, R. M., et al.:  Association of Hemadsorption Viruses with Respiratory Illness in Childhood , J.A.M.A. 169:548, 1959;.
Chanock, R. M., et al.:  Newly Recognized Myxoviruses from Children with Respiratory Disease , New Engl. J. Med. 258:207, 1958;.
Glaser, J.: Allergy in Childhood , Springfield, Ill., Charles C Thomas, Publisher, 1956;, pp. 175, 188.
Sherman, W. B., and Kessler, W. R.: Allergy in Pediatric Practice , St. Louis, The C. V. Mosby Company, 1957;, p. 166.
Buffum, W. P.:  Asthma in Infancy , Rhode Island Med. J. 41:134, 1958;.
Boesen, I.:  Asthmatic Bronchitis in Children , Acta Pediat. 42:87, 1953;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

Rackemann, F. M.; Ratner, B., and Sulzberger, M. B.:  Round Table Discussion on Allergy in Children , J. Pediat. 9:808, 1936;.
Feinberg, S. M.: Allergy in Practice , Chicago, Year Book Medical Publishers, Inc., 1946;, pp. 88-90.
Cooke, R. A.: Allergy in Theory and Practice , Philadelphia, W. B. Saunders Company, 1947;, pp. 130-131.
Danilović, V.:  Le Role des infections des bronches dans l'asthme , Acta Allerg. (Kbh.) 14: 122, 1959;.
Feingold, B. F.:  Infection in Bronchial Allergic Disease , Pediat. Clin. N. Amer. 6:709, 1959;.
Tuft, L.:  Bronchial Asthma: A Critical Review , J. Allergy 17:27, 1946;.
Feingold, B. F.:  The Influence of Acute Infection upon the Course of Allergy in Children , J. Pediat. 34:545, 1949;.
Chanock, R. M., et al.:  Respiratory Syncytial Virus: I. Virus Recovery and Other Observations During 1960 Outbreak of Bronchiolitis, Pneumonia, and Minor Respiratory Diseases in Children , J.A. M.A. 176:647, 1961;.
Parrott, R. H., et al.:  Respiratory Syncytial Virus: II. Serologic Studies over a 34-Month Period of Children with Bronchiolitis, Pneumonia, and Minor Respiratory Diseases , J.A.M.A. 176: 653, 1961;.
Parrott, R. H.:  Newly Isolated Viruses in Respiratory Disease , Pediatrics 20:1066, 1957;.
Parrott, R. H., et al.:  Clinical Features of Infection with Hemadsorption Viruses , New Engl. J. Med. 260:731, 1959;.
Parrott, R. H.: Personal communication to the authors.
Chanock, R. M., et al.:  Association of Hemadsorption Viruses with Respiratory Illness in Childhood , J.A.M.A. 169:548, 1959;.
Chanock, R. M., et al.:  Newly Recognized Myxoviruses from Children with Respiratory Disease , New Engl. J. Med. 258:207, 1958;.
Glaser, J.: Allergy in Childhood , Springfield, Ill., Charles C Thomas, Publisher, 1956;, pp. 175, 188.
Sherman, W. B., and Kessler, W. R.: Allergy in Pediatric Practice , St. Louis, The C. V. Mosby Company, 1957;, p. 166.
Buffum, W. P.:  Asthma in Infancy , Rhode Island Med. J. 41:134, 1958;.
Boesen, I.:  Asthmatic Bronchitis in Children , Acta Pediat. 42:87, 1953;.

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