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Closed Partial Perfusion in Puppies

Am J Dis Child. 1962;104(3):296-301. doi:10.1001/archpedi.1962.02080030298013.
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The idea that life may be preserved in patients with cardiovascular failure by means of extracorporeal circulation has formed the basis of much research in recent years.1-5 That such techniques might be applicable to newborn and premature infants with cardiac or respiratory distress cannot be determined until suitable methods are developed for long-term perfusion in this type of patient. Although some of the information obtained from experiments in older animals is applicable, the sensitivity and control of the various systems reported to date are quite inadequate for small subjects. Moreover, it must be appreciated that much of the available physiological data may not be pertinent in the less mature animals, and such aspects of perfusion still require study. It is the purpose of this paper to report the preliminary results with a newly developed extracorporeal pump oxygenating system mechanically suitable for puppies of a weight equivalent to that of


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