0
September 1962, Vol 104, No. 3 >
Article | September 1962

Prolonged Use of Oral Neomycin in Premature Infants FREE

KATHLEEN CARNEY BUETOW, M.D., DR. P. H.; CHE-SUN CHEUNG, M.D.; LAURENCE FINBERG, M.D.
[+] Author Affiliations

Submitted for publication Oct. 17, 1961.

This study was supported in part by the Highlandtown Exchange Club Fund and U.S. Public Health Service Grant B 1409.


Am J Dis Child. 1962;104(3):252-257. doi:10.1001/archpedi.1962.02080030254007.
Text Size: A A A
Published online
Article
References
Comments

Neomycin given orally has proved to be a useful drug in controlling several forms of epidemic diarrhea of the newborn, principally that presumably due to enteropathic strains of Escherichia coli. During an epidemic period such nursery outbreaks of diarrheal illness are best controlled by administering this drug, in the dosage range of 100 mg. per kilogram per day to all susceptible infants and maintaining them on the drug for at least 6 days and possibly until the time of their discharge from the nursery.1-5 In the premature nursery this may necessitate the administration of neomycin for periods of 3 weeks or longer and raises the question of the safety of prolonged usage. This query becomes particularly pertinent in the light of recent reports indicating that many antimicrobials (e.g., sulfisoxazole, chloramphenicol, and novobiocin) cannot be administered with impunity to newborns in dosages found safe for older infants and adults.6-8

REFERENCES

1 +
Wheeler, W. E., and Wainerman, B.:  The Treatment and Prevention of Epidemic Infantile Diarrhea Due to E. Coli O-111 by the Use of Chloramphenicol and Neomycin , Pediatrics 14:357, 1954;.
2 +
Stulberg, C. S.; Zuelzer, W. W.; Nolke, A. C., and Thompson, A. L.:  Escherichia Coli 0127: B8, a Pathogenic Strain Causing Infantile Diarrhea , A.M.A. Amer. J. Dis. Child. 90:125, 1955;.
3 +
Stulberg, C. S.; Zuelzer, W. W., and Nolke, A. C.:  An Epidemic of Diarrhea of the Newborn Caused by Escherichia Coli O-111, B4 , Pediatrics 14: 133, 1954;.
4 +
Wheeler, W. E., and Wainerman, B.:  The Treatment and Prevention of Epidemic Infantile Diarrhea Associated with Escherichia Coli O111 by Use of Chloramphenicol and Neomycin , A.M.A. Amer. J. Dis. Child. 86:350, 1953;.
5 +
Cooper, M. L.; Walters, E. W., and Keller, H. M.:  Escherichia Coli Associated with Infantile Diarrhea , Ann. N.Y. Acad. Sci. 66:78, 1956;.
6 +
Silverman, W. A.; Andersen, D. H.; Blanc, W. A., and Crozier, D. N.:  A Difference in Mortality Rate and Incidence of Kernicterus Among Premature Infants Allotted to 2 Prophylactic Antibacterial Regimens , Pediatrics 18:614, 1956;.
7 +
Sutherland, J. M.:  Fatal Cardiovascular Collapse of Infants Receiving Large Amounts of Chloramphenicol , A.M.A. J. Dis. Child. 97:761, 1959;.
8 +
Sutherland, J. M., and Keller, W. H.:  Novobiocin and Neonatal Hyperbilirubinemia , Amer. J. Dis. Child. 101:447, 1961;.
9 +
Directions for Use of Acuplastin, Ortho Pharmaceutical Corporation, Raritan, N.J.
10 +
Cotlove, E.; Trantham, H. V., and Bowman, R. L.:  An Instrument and Method for Automatic, Rapid, Accurate, and Sensitive Titration of Chloride in Biologic Samples , J. Lab. Clin. Med. 51:461, 1958;.
11 +
Archibald, R. M.; Ortiz, P.; Stroh, E., and Bronner, J.:  Colorimetric Determination of Urea , J. Biol. Chem. 157:507, 1945;.
12 +
Last, P. M., and Sherlock, S.:  Systemic Absorption of Orally Administered Neomycin in Liver Disease , New Engl. J. Med. 262:385, 1960;.
13 +
Lechevalier, H. A., in Neomycin: Its Nature and Practical Application , edited by S. A. Waksman, Baltimore, Williams & Wilkins Company, 1958;.
14 +
Neter, E., in, Neomycin: Its Nature and Practical Application.13
15 +
Kempe, C. H.:  Pediatric Use of Antibacterial Agents , J. Pediat. 53:19, 1958;.
16 +
Waisbren, B. A., and Spink, W. W.:  Clinical Appraisal of Neomycin , Ann. Intern. Med. 33:1099, 1950;.
17 +
Hawkins, J. E., in, Neomycin: Its Nature and Practical Application.13
18 +
Poth, E. J.; From, S. M.; Wise, R. I., and Hsiang, C. M.:  Neomycin, a New Intestinal Antiseptic , Texas Rep. Biol. Med. 8:353, 1950;.
19 +
Kunin, C. M.; Chalmers, T. C.; Leevy, C. M.; Sebastyen, S. C.; Lieber, C. S., and Finland, M.:  Absorption of Orally Administered Neomycin and Kanamycin with Special Reference to Patients with Severe Hepatic and Renal Disease , New Engl. J. Med. 262:380, 1960;.
20 +
Jacobson, E. D.; Chodos, R. B., and Faloon, W. W.:  An Experimental Malabsorption Syndrome Induced by Neomycin , Amer. J. Med. 28:524, 1960;.
21 +
Faloon, W. W.; Fisher, C. J., and Duggan, K. C.:  Occurrence of a Sprue-like Syndrome During Neomycin Therapy , J. Clin. Invest. 37:893, 1958;.
22 +
Meyer, T. C., and Angus, J.:  The Effect of Large Doses of 'Synkavit' in the Newborn , Arch. Dis. Child. 31:212, 1956;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Wheeler, W. E., and Wainerman, B.:  The Treatment and Prevention of Epidemic Infantile Diarrhea Due to E. Coli O-111 by the Use of Chloramphenicol and Neomycin , Pediatrics 14:357, 1954;.
2 +
Stulberg, C. S.; Zuelzer, W. W.; Nolke, A. C., and Thompson, A. L.:  Escherichia Coli 0127: B8, a Pathogenic Strain Causing Infantile Diarrhea , A.M.A. Amer. J. Dis. Child. 90:125, 1955;.
3 +
Stulberg, C. S.; Zuelzer, W. W., and Nolke, A. C.:  An Epidemic of Diarrhea of the Newborn Caused by Escherichia Coli O-111, B4 , Pediatrics 14: 133, 1954;.
4 +
Wheeler, W. E., and Wainerman, B.:  The Treatment and Prevention of Epidemic Infantile Diarrhea Associated with Escherichia Coli O111 by Use of Chloramphenicol and Neomycin , A.M.A. Amer. J. Dis. Child. 86:350, 1953;.
5 +
Cooper, M. L.; Walters, E. W., and Keller, H. M.:  Escherichia Coli Associated with Infantile Diarrhea , Ann. N.Y. Acad. Sci. 66:78, 1956;.
6 +
Silverman, W. A.; Andersen, D. H.; Blanc, W. A., and Crozier, D. N.:  A Difference in Mortality Rate and Incidence of Kernicterus Among Premature Infants Allotted to 2 Prophylactic Antibacterial Regimens , Pediatrics 18:614, 1956;.
7 +
Sutherland, J. M.:  Fatal Cardiovascular Collapse of Infants Receiving Large Amounts of Chloramphenicol , A.M.A. J. Dis. Child. 97:761, 1959;.
8 +
Sutherland, J. M., and Keller, W. H.:  Novobiocin and Neonatal Hyperbilirubinemia , Amer. J. Dis. Child. 101:447, 1961;.
9 +
Directions for Use of Acuplastin, Ortho Pharmaceutical Corporation, Raritan, N.J.
10 +
Cotlove, E.; Trantham, H. V., and Bowman, R. L.:  An Instrument and Method for Automatic, Rapid, Accurate, and Sensitive Titration of Chloride in Biologic Samples , J. Lab. Clin. Med. 51:461, 1958;.
11 +
Archibald, R. M.; Ortiz, P.; Stroh, E., and Bronner, J.:  Colorimetric Determination of Urea , J. Biol. Chem. 157:507, 1945;.
12 +
Last, P. M., and Sherlock, S.:  Systemic Absorption of Orally Administered Neomycin in Liver Disease , New Engl. J. Med. 262:385, 1960;.
13 +
Lechevalier, H. A., in Neomycin: Its Nature and Practical Application , edited by S. A. Waksman, Baltimore, Williams & Wilkins Company, 1958;.
14 +
Neter, E., in, Neomycin: Its Nature and Practical Application.13
15 +
Kempe, C. H.:  Pediatric Use of Antibacterial Agents , J. Pediat. 53:19, 1958;.
16 +
Waisbren, B. A., and Spink, W. W.:  Clinical Appraisal of Neomycin , Ann. Intern. Med. 33:1099, 1950;.
17 +
Hawkins, J. E., in, Neomycin: Its Nature and Practical Application.13
18 +
Poth, E. J.; From, S. M.; Wise, R. I., and Hsiang, C. M.:  Neomycin, a New Intestinal Antiseptic , Texas Rep. Biol. Med. 8:353, 1950;.
19 +
Kunin, C. M.; Chalmers, T. C.; Leevy, C. M.; Sebastyen, S. C.; Lieber, C. S., and Finland, M.:  Absorption of Orally Administered Neomycin and Kanamycin with Special Reference to Patients with Severe Hepatic and Renal Disease , New Engl. J. Med. 262:380, 1960;.
20 +
Jacobson, E. D.; Chodos, R. B., and Faloon, W. W.:  An Experimental Malabsorption Syndrome Induced by Neomycin , Amer. J. Med. 28:524, 1960;.
21 +
Faloon, W. W.; Fisher, C. J., and Duggan, K. C.:  Occurrence of a Sprue-like Syndrome During Neomycin Therapy , J. Clin. Invest. 37:893, 1958;.
22 +
Meyer, T. C., and Angus, J.:  The Effect of Large Doses of 'Synkavit' in the Newborn , Arch. Dis. Child. 31:212, 1956;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems