To the Editor: I wish to refer to the communication made at the 31st Annual Meeting of the Society for Pediatric Research by Watson, R. J.; Burko, H.; Megas, H., and Robinson, M., summarized in your Journal (102:603) entitled: "The Hand-Foot Syndrome in Sickle-Cell Disease in Children."
This syndrome is well known in African children for the past decade. Its frequency and incidence according to age, its clinical and radiographic characteristics as well as its evolution, have been described in detail ever since the first works of Lambotte-Legrand,1,2 dealing with sickle-cell anemia in native children from the Congo (1951). Similar descriptions of the syndrome have been published by the same authors (1952, 1958),3,4 as well as by Trowell and co-workers (1957).5
Infectious complications of this syndrome, mentioned with the first description of this syndrome, have been especially studied in the field of salmonella osteitis in sickle-cell anemia