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Viruses and Cancer

ROBERT M. McALLISTER, M.D.; CLYDE R. GOODHEART, M.D.
Am J Dis Child. 1962;104(1):87-96. doi:10.1001/archpedi.1962.02080030089013.
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The current interest in the virus theory of cancer is illustrated by the number of detailed reviews of the role of viruses in the etiology of some animal cancers and their possible role in human cancer.1-6 This review will be limited to certain historical data and to significant new data on certain tumor viruses, as well as recent discussions of the problems of human tumor viruses available since the previous reviews. The purpose of this review will be (1) to describe the historical background of the virus theory of cancer; (2) to present the theories on how a virus may convert a normal cell into a malignant cell. For this purpose, the current concepts of a normal cell, a cancer cell, and a virus will be described. Further, the purpose will be (3) to describe certain significant new data concerning virus-induced neoplasia in cells cultivated in vitro and in

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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