0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Potency Measurement of Inactivated Measles Vaccines

JOEL WARREN, Ph.D.; JAMES G. CRAWFORD, Ph.D.; MARY JAYNE GALLIAN, B.S.
Am J Dis Child. 1962;103(3):452-457. doi:10.1001/archpedi.1962.02080020464063.
Text Size: A A A
Published online

Individuals who are converted to a seropositive state by the administration of adequate amounts of a killed measles antigen develop resistance to natural and attenuated measles infection.1,2 This immunity is not dependent upon the maintenance of an elevated antibody titer. It, therefore, seems reasonable to postulate that the level of clinical effectiveness of a specific lot of an inactivated measles vaccine would be correlated with its immunogenic potency in animals. The following report (in which the available data have been condensed because of limitations of time) describes a standard vaccine assay procedure and certain studies on measles virus and host factors which led to its development.

Virus Considerations  All of the antigenic activity of measles virus appears to be associated with the particle itself, i.e., there is no evidence of a soluble antigen. However, the estimation of virus concentration by infectivity titration alone provides only a rough index, because

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();