In Session 4, dealing with immunization of man against measles, 3 different facets were reported upon, the first being electroencephalographic evidence of little or no effect on the central nervous system by attenuated vaccine, both in monkey and man; in the second, reports of trials in various disease states were presented, and in the third, the development and trials of inactivated virus vaccine were described.
Dr. Rosenthal stated that out of 84 patients with measles encephalitis, 100% showed exceedingly slow electroencephalographic activity. Although clinical recovery occurred fairly early in as many as 50%, some EEG abnormalities might persist.
Among 680 patients with uncomplicated measles, 51% had slow electroencephalographic tracings, most frequently observed in children up to 3 years. In most, neither clinical nor electroencephalographic residuals were noted. Convulsions during measles were more frequent in children with preexisting abnormal EEG patterns than in those who showed no abnormality.
In order to