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March 1962, Vol 103, No. 3 >
Article | March 1962

Field Trial of Inactivated Measles Vaccine FREE

DAVID T. KARZON, M.D.; WARREN WINKELSTEIN, M.D.; RACHEL JENSS, SC.D.; GLEN E. GRESHAM, M.D.; WILLIAM E. MOSHER, M.D.
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Presented at the International Conference on Measles Immunization, National Institutes of Health, Bethesda, Md., Nov. 7-9, 1961.


Am J Dis Child. 1962;103(3):425-426. doi:10.1001/archpedi.1962.02080020437054.
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Introduction and Methods  A "double-blind" field trial of the alum-precipitated, concentrated, inactivated measles vaccine developed by Warren1,2 was carried out in the kindergartens and first grades of 15 schools in Buffalo beginning March 20, 1961.3 A total of 330 children received vaccine and 319 placebo. Vaccine and placebo were administered intramuscularly in 3 doses of 0.5 cc. The first 2 injections were a week apart, and the third was given 4 weeks after the first. Within each classroom, study participants were alternated between vaccine and placebo groups.Serologic studies were carried out on a sample of 40 children. Measles surveillance was begun at the time of the first injection and continued until the closing of school on June 23.

Results  Comparison of the vaccine and placebo groups with respect to age, race, sex, socioeconomic status, and number of individuals in each household under 15 years of age revealed

REFERENCES

1 +
Warren, J., and Gallian, M. J.:  Concentrated Inactivated Measles-Virus Vaccine: I. Preparation and Antigenic Potency , Amer. J. Dis. Child. 103: this issue, page 418.
2 +
Feldman, H. A.; Novak, A., and Warren, J.: Inactivated Measles Vaccine: II. Prevention of Natural and Experimental Measles, to be published.
3 +
Winkelstein, W., Jr.; Jenss, R.; Gresham, G. E.; Karzon, D. T., and Mosher, W. E.: Inactivated Measles Vaccine: III. A Field Trial in Young School Children, to be published.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Warren, J., and Gallian, M. J.:  Concentrated Inactivated Measles-Virus Vaccine: I. Preparation and Antigenic Potency , Amer. J. Dis. Child. 103: this issue, page 418.
2 +
Feldman, H. A.; Novak, A., and Warren, J.: Inactivated Measles Vaccine: II. Prevention of Natural and Experimental Measles, to be published.
3 +
Winkelstein, W., Jr.; Jenss, R.; Gresham, G. E.; Karzon, D. T., and Mosher, W. E.: Inactivated Measles Vaccine: III. A Field Trial in Young School Children, to be published.

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