0
March 1962, Vol 103, No. 3 >
Article | March 1962

Separation of Measles Virus Particles in Density Gradients

ANN E. SCHLUEDERBERG, Sc.D.
Am J Dis Child. 1962;103(3):291-296. doi:10.1001/archpedi.1962.02080020303023.
Text Size: A A A
Published online
Article
References
Comments

The chemical and physical properties of measles virus have been difficult to ascertain due to the instability of the virus and low yields obtainable in tissue culture.

Whether by a chance adaptation of the virus to our line of HEP 2 cells or as a result of modifications in growth conditions, we have been fortunate in our laboratory in producing measles virus in concentrations which lend themselves to quantitative analysis. Preparations with complement fixing (CF) titers of 1:16 or greater and containing from 107 to 108 tissue culture infectious doses per milliliter have been obtained regularly. Further concentration could be effected by osmotically forced dialysis using polyethylene glycols 1 or by sedimentation.

The present study was initiated in the hope that fractionation of measles virus concentrates, with respect to density, might reveal the presence of specific viral substances or particles differing not only in density but also in

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems