To the Editor: Dr. Mathies' findings (Amer. J. Dis. Child. 101:174, 1961), relative to pinworm-host relations have afforded me an opportunity to offer a speculation or two on the control and cure of pinworm infestations in routine pediatric practice. Dr. Mathies made a number of interesting points: he found that a moderate daily dose of piperazine citrate for 7 days did a good, painless job of pinworm extermination; whereas 2 massive doses of the drug a week apart did no better and produced a lot of bellyache. He also found that when many youngsters live together, almost all of them become infested with pinworms, but that older children are less subject than small-fry to infestation (and adults least of all).
My first speculation has to do with drug therapy in general, and may be stated thus: whereas a new drug may be good, an even newer drug or drug dosage