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May 1961, Vol 101, No. 5 >
Article | May 1961

Poliomyelitis Vaccination with Live Poliovirus FREE

F. BUSER, M.D.; M. SCHAR, M.D.
[+] Author Affiliations

Submitted for publication Oct. 7, 1960.

Bühlstr. 40.

The preliminary results of this paper were presented at the Ninth International Congress of Pediatrics, in Montreal, July 19-25, 1959.

Both were kindly provided by Dr. Koprowski.


Am J Dis Child. 1961;101(5):568-574. doi:10.1001/archpedi.1961.04020060026003.
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References
Comments

Until the year 1958, reports were available only on small numbers of persons vaccinated against poliomyelitis with live attenuated polio virus. Practically all information had been obtained from isolated or semi-isolated groups in institutions.

Early in 1958, we began one of the first field trials with live polio vaccine, a controlled study of vaccination in nonisolated infants and children of the city of Bern, Switzerland.1 Since then, more than 80,000,000 people in various countries have been vaccinated with live poliovirus, and many of the problems associated with this form of vaccine have been solved.

The purpose of our study was to obtain information about the following questions raised by this new method of vaccination:

  1. The immunogenic properties of the live avirulent polio vaccine

  2. The rate of intestinal infection and the duration of virus excretion

  1. The spread of the vaccine virus from vaccinated persons to nonimmune contacts

REFERENCES

1 +
Buser, F., and Schär, M.:  Schutzimpfung gegen Poliomyelitis mit lebenden avirulenten Viren , Schweiz. Med. Wschr. 88:1282, 1958;.
2 +
Koprowski, H.:  Discussion on Properties of Attenuated Polioviruses and Their Behavior in Human Beings , Spec. Publ. New York Acad. Sci. 5:128, 1957;.
3 +
Koprowski, H.:  Zur Geschichte der Impfung mit Poliomyelitis Lebendvakzine , Schweiz. Med. Wschr. 89:1323, 1959;.
4 +
Murray, R., and others: Comparative Virulence for Rhesus Monkeys of Poliovirus Strains Used for Oral Administration, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 39.
5 +
Buser, F.:  Der gegenwärtige Stand der Poliomyelitisschutzimpfung mit lebenden avirulenten Polioviren , Schweiz. Med. Wschr. 90:44, 1960;.
6 +
Koprowski, H.: The Role of Markers of Poliovirus in Attempts to Identify Strains Isolated from Man During a Mass Vaccination Program, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 135.
7 +
Koprowski, H., and others:  Genetic Markers and Serologic Identity of Wild and Attenuated Strains of Type 1 Poliovirus, with Special Emphasis on Strains Isolated from Patients During an Epidemic in the Belgian Congo , Bull. WHO , 1960;.
8 +
Koprowski, H.:  Importance of Genetics of Viruses in Medical Research , J. Med. Educ. 34: 335, 1959;.
9 +
Plotkin, S. A., and others: Vaccination of Families Against Poliomyelitis by Feeding and by Contact Spread of Living Attenuated Virus: Including Studies of Virus Properties After Human Intestinal Passage, Acta Paediat. (Upps.), to be published.
10 +
Sabin, A. B.:  Present Position of Immunization Against Poliomyelitis with Live Virus Vaccines , Brit. Med. J. 1:663, 1959;.
11 +
Sabin, A. B.: Criteria of Attenuation, Development, Selection, and Testing of Poliovirus Strains for Use in Field Trials, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 14.
12 +
Pagano, J. S., and others:  Routine Immunization with Orally Administered Attenuated Poliovirus , J.A.M.A. 173:1883, 1960;.
13 +
Przesmycki, F. H., and others: Report on Field Trials with Live Attenuated Poliomyelitis Vaccine in Poland, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 497.
14 +
Koprowski, H., and others: Behavior of Attenuated Strains of Poliomyelitis Virus in Relation to Age, Familial Spread and Duration of Immunity, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 159.
15 +
Gelfand, H. M., and others: Revised Preliminary Report on the Louisiana Observations of the Natural Spread Within Families of Living Vaccine Strains of Poliovirus, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 203.
16 +
Gerloff, R. K.; Larson, C. L., and Glesne, L. R. B.:  Naturally Occurring Poliomyelitis Antibody in Hamilton, Montana , Public Health Rep. 74:175, 1959;.
17 +
Fox, J. P., and others: Studies on the Development of Natural Immunity to Poliomyelitis in Louisiana: I.  Over-All Plan, Methods and Observations as to Patterns of Seroimmunity in the Study Group , Amer. J. Hyg. 65:344, 1957;.
18 +
Plotkin, S. A., and others:  Persistence of Antibodies After Vaccination with Living Attenuated Poliovirus , J.A.M.A. 170:8, 1959;.
19 +
Sabin, A. B.: Personal communication to the authors.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Buser, F., and Schär, M.:  Schutzimpfung gegen Poliomyelitis mit lebenden avirulenten Viren , Schweiz. Med. Wschr. 88:1282, 1958;.
2 +
Koprowski, H.:  Discussion on Properties of Attenuated Polioviruses and Their Behavior in Human Beings , Spec. Publ. New York Acad. Sci. 5:128, 1957;.
3 +
Koprowski, H.:  Zur Geschichte der Impfung mit Poliomyelitis Lebendvakzine , Schweiz. Med. Wschr. 89:1323, 1959;.
4 +
Murray, R., and others: Comparative Virulence for Rhesus Monkeys of Poliovirus Strains Used for Oral Administration, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 39.
5 +
Buser, F.:  Der gegenwärtige Stand der Poliomyelitisschutzimpfung mit lebenden avirulenten Polioviren , Schweiz. Med. Wschr. 90:44, 1960;.
6 +
Koprowski, H.: The Role of Markers of Poliovirus in Attempts to Identify Strains Isolated from Man During a Mass Vaccination Program, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 135.
7 +
Koprowski, H., and others:  Genetic Markers and Serologic Identity of Wild and Attenuated Strains of Type 1 Poliovirus, with Special Emphasis on Strains Isolated from Patients During an Epidemic in the Belgian Congo , Bull. WHO , 1960;.
8 +
Koprowski, H.:  Importance of Genetics of Viruses in Medical Research , J. Med. Educ. 34: 335, 1959;.
9 +
Plotkin, S. A., and others: Vaccination of Families Against Poliomyelitis by Feeding and by Contact Spread of Living Attenuated Virus: Including Studies of Virus Properties After Human Intestinal Passage, Acta Paediat. (Upps.), to be published.
10 +
Sabin, A. B.:  Present Position of Immunization Against Poliomyelitis with Live Virus Vaccines , Brit. Med. J. 1:663, 1959;.
11 +
Sabin, A. B.: Criteria of Attenuation, Development, Selection, and Testing of Poliovirus Strains for Use in Field Trials, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 14.
12 +
Pagano, J. S., and others:  Routine Immunization with Orally Administered Attenuated Poliovirus , J.A.M.A. 173:1883, 1960;.
13 +
Przesmycki, F. H., and others: Report on Field Trials with Live Attenuated Poliomyelitis Vaccine in Poland, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 497.
14 +
Koprowski, H., and others: Behavior of Attenuated Strains of Poliomyelitis Virus in Relation to Age, Familial Spread and Duration of Immunity, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 159.
15 +
Gelfand, H. M., and others: Revised Preliminary Report on the Louisiana Observations of the Natural Spread Within Families of Living Vaccine Strains of Poliovirus, presented at First International Conference on Live Poliovirus Vaccines, Washington, D.C., Pan American Health Organization, 1959, p. 203.
16 +
Gerloff, R. K.; Larson, C. L., and Glesne, L. R. B.:  Naturally Occurring Poliomyelitis Antibody in Hamilton, Montana , Public Health Rep. 74:175, 1959;.
17 +
Fox, J. P., and others: Studies on the Development of Natural Immunity to Poliomyelitis in Louisiana: I.  Over-All Plan, Methods and Observations as to Patterns of Seroimmunity in the Study Group , Amer. J. Hyg. 65:344, 1957;.
18 +
Plotkin, S. A., and others:  Persistence of Antibodies After Vaccination with Living Attenuated Poliovirus , J.A.M.A. 170:8, 1959;.
19 +
Sabin, A. B.: Personal communication to the authors.

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