Article |

Phenylketonuria—Treating the Disease and Feeding the Child

Am J Dis Child. 1960;100(6):908-913. doi:10.1001/archpedi.1960.04020040910016.
Text Size: A A A
Published online

With the current interest in phenylketonuria surveys and case-finding programs, many questions are being asked about the use of the low-phenylalanine basal mix and the low-phenylalanine diet. It is the purpose of this paper to present the experiences and observations of the research team studying metabolic errors at the Children's Hospital Research Foundation, Cincinnati, Ohio.

Investigators generally agree that the administration of low-phenylalanine diets to phenylketonuric children is of most advantage if begun very early in life, preferably within the first six months.1,2 However, in the light of reports of some improvement in older children,3,4 and owing to lack of other therapy, 10 phenylketonuric children between the ages of 9 months and 7 years were placed on low-phenylalanine diets. The group included three pairs of affected siblings. Mental ability ranged from near normal in two cases to severely affected.

Serum phenylalanine concentrations, urinary amino acid, phenolic acid, and


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.