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December 1960, Vol 100, No. 6 >
Article | December 1960

Atropine Sensitivity and Serotonin in Mongolism FREE

DONOUGH O'BRIEN, M.D., M.R.C.P.; M. WILHELMINA HAAKE, M.D.; BONNIE BRAID, B.Sc.
[+] Author Affiliations

Submitted for publication April 4, 1960.

Dr. O'Brien is a John and Mary Markle Foundation Scholar in Medical Sciences.

Supported in part by funds from U.S.P.H.S. grant No. M-2347 and by Ross Laboratories.


Am J Dis Child. 1960;100(6):873-874. doi:10.1001/archpedi.1960.04020040875012.
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It has been reported1 that children with Mongolism demonstrate an idiosyncrasy to atropine with a significantly increased rate of pupillary dilatation after conjunctival instillation. One possible explanation of this hypersensitivity may be that in Mongolism there is a diminished availability of some natural antagonist to atropine. Now one such substance is serotonin which has been shown to have an action in pharmacological opposition to atropine in rabbit intestine2 and guinea pig ileum.3 Moreover, we have found that in Mongolism there is a decreased urinary excretion of 5-hydroxyindoleacetic acid,4 the end-product of serotonin. The mean seven-hour excretion of 5-HIAA after an oral dose of 250 mg/kg. dl-tryptophan was 47μg/kg. for 16 children with Mongolism as opposed to 66.0μg/kg. for 13 normal controls. While these differences are probably not significant by the Aspin Welch Test5 (p = <0.1 and >0.05), a similar trend was shown in another

REFERENCES

1 +
Berg, J. M.; Brandon, M. W. G., and Kirman, B. H.:  Atropine in Mongolism , Lancet 2: 441, 1959;.
2 +
Ferguson, J.:  Action of Serotonin on Motility of Aneural Smooth Muscle , Fed. Proc. 16:37, 1957;.
3 +
Robertson, P. A.:  An Antagonism of 5-Hydroxytryptamine by Atropine , J. Physiol. 121:54P, 1953;.
4 +
O'Brien, D.; Groshek, A. P., and Streamer, C. W.: Abnormalities of Tryptophane Metabolism in Children with Mongolism, A.M.A. J. Dis. Child., to be published.
5 +
Trickett, W. H.; Welch, B. L., and Adams, G. S.:  Further Values for the Two-Means Problem , Biometrika 43:203, 1956;.
6 +
Gershoff, S. N.: Personal Communication.

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References

1 +
Berg, J. M.; Brandon, M. W. G., and Kirman, B. H.:  Atropine in Mongolism , Lancet 2: 441, 1959;.
2 +
Ferguson, J.:  Action of Serotonin on Motility of Aneural Smooth Muscle , Fed. Proc. 16:37, 1957;.
3 +
Robertson, P. A.:  An Antagonism of 5-Hydroxytryptamine by Atropine , J. Physiol. 121:54P, 1953;.
4 +
O'Brien, D.; Groshek, A. P., and Streamer, C. W.: Abnormalities of Tryptophane Metabolism in Children with Mongolism, A.M.A. J. Dis. Child., to be published.
5 +
Trickett, W. H.; Welch, B. L., and Adams, G. S.:  Further Values for the Two-Means Problem , Biometrika 43:203, 1956;.
6 +
Gershoff, S. N.: Personal Communication.

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