Cushing's syndrome in children is usually the result of a tumor of the adrenal cortex. Only rarely has the syndrome occurred in the absence of a neoplasm prior to the age of 10 years. The purpose of this report is to present a proved case of Cushing's syndrome with hyperplasia of the adrenal cortex in a child in whom the clinical manifestations first appeared at the age of 8 years.
Report of Case
The patient was born in February, 1947, and has been cared for by one of us (M. G.) from early infancy. Her early physical development was normal. She had been a relatively slender child (Fig. 1), who was said to have been a "poor eater." When she was approximately 8 years of age she was fitted with a dental appliance in an attempt to stop her from sucking her thumb. Shortly thereafter there was a marked increase