We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Toxicity of Chloramphenicol in Newborns Versus Adult Mice

Am J Dis Child. 1960;100(3):400-404. doi:10.1001/archpedi.1960.04020040402013.
Text Size: A A A
Published online


Glucuronide conjugation is an important mechanism in the detoxification of chloramphenicol.1 The ability of normal adults to conjugate chloramphenicol, bilirubin, etc., with glucuronide is well established. Recent studies indicate that newborn mice, guinea pigs, and humans have a poorly developed glucuronide-conjugating mechanism.2-4 Presumably the young of other species may show a similar deficit. In such cases, drugs that are ordinarily detoxified by glucuronide conjugation thus may accumulate and more often reach toxic levels. Recent clinical reports suggest that chloramphenicol is more toxic in newborn human infants than in adults.5-7 The data on humans are limited and difficult to interpret because of inadequately controlled variables. Some experimental evaluation of chloramphenicol in the newborn versus adults therefore is desirable.

Methods  Forty-four litters containing a total of 394 newborn white mice of the CFW strain* were used in this study. Within 24 hours after birth, the newborns were weighed and


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.