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Fatal Exfoliative Dermatitis Following Injection of Triple Antigen and Salk Vaccine

Am J Dis Child. 1960;100(2):282-285. doi:10.1001/archpedi.1960.04020040284020.
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Over the past several years, reports have appeared in the literature concerning reactions to the Triple Antigen—diphtheria, pertussis, and tetanus (DPT). These have been primarily concerned with anaphylactic or convulsive type of reaction. In recent years several reports of toxic reaction to poliomyelitis vaccine also appeared in the literature.

In this case report, the patient received both vaccines at the same time. It has been impossible to definitely incriminate either vaccine in this instance. The result was of such severity, however, that it was thought to be worth reporting.

Report of Case  The patient was born on Feb. 17, 1958. Her prenatal and neonatal history was normal and uneventful. Birth weight was 7 lb. 8 oz. (3,400 gm.) and length 20½ in.Her family history revealed drug sensitization in her mother and allergic rhinitis in her two maternal uncles. She has a living sibling, age 2 years, who shows no


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