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Congenital Generalized Indifference to Pain (Congenital Analgia)

Am J Dis Child. 1960;100(1):124-126. doi:10.1001/archpedi.1960.04020040126019.
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Insensitivity to pain is a rare anomaly. It is congenital, probably recessively inherited and affects the skin and mucous membranes, skeleton, and protopathic sensibility. Infants with this disorder often bite their tongues, fingers, and lips, and the wounds heal slowly. Usually parents note at about the third year the child does not cry when injured and seems indifferent to blows or falls. Injuries and burns are frequent, as are secondary infections. Usually these children do not complain of the injury and will continue happy and active.

We are reporting a child in whom insensitivity to painful stimuli was first noted in the early weeks of life. By 17 months of age the clinical picture was quite definitely that of congenital analgia.

Report of Case  A girl was born in Carle Memorial Hospital on May 20, 1957. The family history was normal, and two older siblings were well. The parents were


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