0
June 1960, Vol 99, No. 6 >
Article | June 1960

The Use of Intramuscular Iron in the Prophylaxis of the Iron-Deficiency Anemia of Prematurity FREE

SANFORD L. LEIKIN, M.D.
[+] Author Affiliations

Submitted for publication Aug. 27, 1959.

2125 13th St., N.W.

Supported by a grant from the Lakeside Laboratories.


AMA Am J Dis Child. 1960;99(6):739-745. doi:10.1001/archpedi.1960.02070030741007.
Text Size: A A A
Published online
Article
References
Comments

Iron-deficiency anemia is still the most prevalent anemia occurring in infancy, despite modern knowledge concerning iron metabolism and the causation of this deficiency state. The premature infant is extremely vulnerable to iron deficiency because his total body hemoglobin available for use is smaller and his growth rate is usually greater than that of the full-term infant. Recently an iron-dextran complex has been found to be effective in supplying the human organism parenterally with large quantities of iron for hemoglobin synthesis. The preparation1 is a third as toxic in mice as saccharated iron oxide solutions. It has been used widely for the treatment of iron deficiency of children2-4 and adults.5,6 It was felt worth while to evaluate its use in the prevention of the late (iron-deficiency) anemia of prematurity.

This report concerns observations of two groups of infants born prematurely who were examined hematologically until one year of

REFERENCES

1 +
Fletcher, F., and London, E.:  Intravenous Iron , Brit. M.J. 1:984, 1954;.
2 +
Gaisford, W., and Jennison, R. F.:  Intramuscular Iron in Infancy , Brit. M.J. 2:700, 1955;.
3 +
Wallerstein, R. O.:  Intramuscular Iron for the Treatment of Iron Deficiency Anemia in Infancy , J. Pediat. 49:173, 1956;.
4 +
Yu, W. L.; Manonmani, K., and Watson, R. J.:  Comparison of Intramuscular Iron-Dextran and Oral Ferrous Sulfate in the Treatment of Iron Deficiency of Anemia , J. Pediat. 54:50, 1959;.
5 +
Cappell, D. F.; Hutchinson, H. E.; Hendry, E. B., and Conway, H.:  A New Carbohydrate Hematinic for Intramuscular Use , Brit. M.J. 2: 1255, 1954;.
6 +
Grunberg, A., and Blair, J. L.:  Intramuscular Iron , Brit. M.J. 1:788, 1955;.
7 +
Schulman, I., and Smith, C. H.:  The Blood Volume in Premature Infants , A.M.A. Am. J. Dis. Child. 88:575, 1954;.
8 +
Sturgeon, P.: Clinical Aspects of Iron Metabolism in Childhood: Normal Requirements, Proceedings of the Ross Conference on Metabolism and Function of Iron, Columbus, Ohio, Ross Laboratories, 1956.
9 +
Hess, J. H., and Lundeen, E. C.: The Premature Infant , Philadelphia, J. B. Lippincott Company, 1941;.
10 +
Ramsay, W. N. M.:  Determination of Iron in Blood Plasma or Serum , Biochem. J. 53:227, 1953;.
11 +
Ventura, S.:  Determination of the Unsaturated Iron Binding Capacity of Serum , J. Clin. Path. 5:271, 1952;.
12 +
Sturgeon, P.: Studies of Iron Requirements in Infants and Children: Iron in Clinical Medicine , Berkeley, University of California Press, 1958;.
13 +
Sturgeon, P.:  Iron Metabolism , Pediatrics 18:267, 1956;.
14 +
Hammond, D., and Murphy, A.:  The Influence of Exogenous Iron on Hemoglobin Formation in the Premature Infant , Clin. Res. 12:53, 1959;.
15 +
Josephs, H. W.:  Absorption of Iron as a Problem in Human Physiology: A Critical Review , Blood 13:1, 1958;.
16 +
Callender, S. T., and Smith, M. D.:  Intramuscular Iron , Brit. M.J. 2:1486, 1954;.
17 +
Shafer, A. W., and Marlow, A. A.:  Toxic Reaction of Intramuscular Injection of Iron , New England J. Med. 260:180, 1959;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Fletcher, F., and London, E.:  Intravenous Iron , Brit. M.J. 1:984, 1954;.
2 +
Gaisford, W., and Jennison, R. F.:  Intramuscular Iron in Infancy , Brit. M.J. 2:700, 1955;.
3 +
Wallerstein, R. O.:  Intramuscular Iron for the Treatment of Iron Deficiency Anemia in Infancy , J. Pediat. 49:173, 1956;.
4 +
Yu, W. L.; Manonmani, K., and Watson, R. J.:  Comparison of Intramuscular Iron-Dextran and Oral Ferrous Sulfate in the Treatment of Iron Deficiency of Anemia , J. Pediat. 54:50, 1959;.
5 +
Cappell, D. F.; Hutchinson, H. E.; Hendry, E. B., and Conway, H.:  A New Carbohydrate Hematinic for Intramuscular Use , Brit. M.J. 2: 1255, 1954;.
6 +
Grunberg, A., and Blair, J. L.:  Intramuscular Iron , Brit. M.J. 1:788, 1955;.
7 +
Schulman, I., and Smith, C. H.:  The Blood Volume in Premature Infants , A.M.A. Am. J. Dis. Child. 88:575, 1954;.
8 +
Sturgeon, P.: Clinical Aspects of Iron Metabolism in Childhood: Normal Requirements, Proceedings of the Ross Conference on Metabolism and Function of Iron, Columbus, Ohio, Ross Laboratories, 1956.
9 +
Hess, J. H., and Lundeen, E. C.: The Premature Infant , Philadelphia, J. B. Lippincott Company, 1941;.
10 +
Ramsay, W. N. M.:  Determination of Iron in Blood Plasma or Serum , Biochem. J. 53:227, 1953;.
11 +
Ventura, S.:  Determination of the Unsaturated Iron Binding Capacity of Serum , J. Clin. Path. 5:271, 1952;.
12 +
Sturgeon, P.: Studies of Iron Requirements in Infants and Children: Iron in Clinical Medicine , Berkeley, University of California Press, 1958;.
13 +
Sturgeon, P.:  Iron Metabolism , Pediatrics 18:267, 1956;.
14 +
Hammond, D., and Murphy, A.:  The Influence of Exogenous Iron on Hemoglobin Formation in the Premature Infant , Clin. Res. 12:53, 1959;.
15 +
Josephs, H. W.:  Absorption of Iron as a Problem in Human Physiology: A Critical Review , Blood 13:1, 1958;.
16 +
Callender, S. T., and Smith, M. D.:  Intramuscular Iron , Brit. M.J. 2:1486, 1954;.
17 +
Shafer, A. W., and Marlow, A. A.:  Toxic Reaction of Intramuscular Injection of Iron , New England J. Med. 260:180, 1959;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems