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May 1960, Vol 99, No. 5 >
Article | May 1960

A Clinical Evaluation of Four Oxyuricides FREE

THOMAS S. BUMBALO, M.D.; LOIS J. PLUMMER, M.D.; J. ROGER WARNER, M.D.
[+] Author Affiliations

Submitted for publication July 16, 1959.

Address: Edward J. Meyer Memorial Hospital (15).


AMA Am J Dis Child. 1960;99(5):617-621. doi:10.1001/archpedi.1960.02070030619007.
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In recent years, attention has been focused on the increased incidence of parasitic diseases in the United States.1,2 Enterobiasis (infection by the pinworm Enterobius vermicularis) is still a common and troublesome pediatric problem, even though many investigators have reported a variety of successful treatments of this parasitic infection.3-6

Simplification of treatment regimens can contribute immeasurably to a decrease in the incidence and a better control of this infection. To date, in a variety of regimens, we have evaluated the following drugs in the treatment of pinworm infection in children: Egressin (thymol-n-isoamylcarbamate), Diphenan (parabenzlphenylcarbamate), methylrosaniline chloride (gentian violet), oxytetracycline, papain, Cremothalidine, (a phthalylsulfathiazole preparation), carbomycin, garlic, piperazine, promethazine hydrochloride, pyrathiazine, and pyrvinium chloride.5,7-10

In a more recent study (5) we reported the results of treatment of 139 children infected with pinworms. Thirty-four children, varying in age and weight, were treated with a single dose of 3

REFERENCES

1 +
Birch, C. L., and Anast, B. P.:  The Changing Distribution of Helminthic Diseases in the United States , J.A.M.A. 164:121, 1957;.
2 +
Bumbalo, T. S., and Stiff, D. W.:  Roentgenologic Diagnosis of Roundworm Infection , New York J. Med. 57:3832, 1957;.
3 +
Brown, H. W.; Chan, K. F., and Hussey, K. L.:  Treatment of Enterobiasis and Ascariasis with Piperazine , J.A.M.A. 161:515, 1956;.
4 +
Miller, J. H.; Anthony, S. O.; Swartzwelder, J. C.; Frye, W. W., and Lampert, R.:  The Treatment of Enterobiasis with Dithiazanine , Am. J. Digest. Dis. (n.s.) 3:229, 1958;.
5 +
Bumbalo, T. S.; Plummer, L. J., and Warner, J. R.:  The Treatment of Enterobiasis in Children: A Comparative Study of Piperazine (Antepar) and Pyrvinium Chloride (Vanquin) , Am. J. Trop. Med. 7:212, 1958;.
6 +
Jenkins, M. E.:  Enterobiasis in Children: The Use of Zinc Oxide Ointment Locally as a Therapeutic Agent , J. Pediat. 50:714, 1957;.
7 +
Bumbalo, T. S.; Gustina, F. J., and Oleksiak, R. E.:  The Treatment of Enterobiasis with Thymyl-N-Isoamylcarbamate (Egressin) , J. Parasitol 39:166, 1953;.
8 +
Bumbalo, T. S.; Gustina, F. J., and Oleksiak, R. E.:  The Treatment of Pinworm Infection (Enterobiasis): A Comparative Study of 3 Oxyuricides , J. Pediat. 44:386, 1954;.
9 +
Bumbalo, T. S.; Plummer, L. J., and Warner, J. R.:  Treatment of Enterobiasis with One Oral Dose of Promethazine Hydrochloride , J.A.M.A. 164:1651, 1957;.
10 +
Bumbalo, T. S.; Gustina, F. J., and Oleksiak, R. E.:  The Treatment of Pinworm Infection with Papain , J. Pediat. 42:576, 1953;.
11 +
Cram, E. B.:  Studies on Oxyuricides: XXVIII. Summary and Conclusion , Am. J. Dis. Child. 65:46, 1943;.
12 +
Swartzwelder, J. C.; Frye, W. W.; Muhleison, J. P.; Miller, J. H., Lampert, R.; Chavarria, A. P.; Abadie, S. H.; Anthony, S. O., and Sappenfield, R. W.:  Dithiazanine: An Effective Broad-Spectrum Anthelmintic: Results of Therapy of Trichuriasis, Strongyloidiasis, Enterobiasis, Ascariasis, and Hookworm Infection , J.A.M.A. 165: 2063, 1957;.
13 +
Bumbalo, T. S., and Gustina, F. J.:  Scientific Exhibit: Treatment of Pinworm Infection in Children , Postgrad. Med. 14:83, 1953;.
14 +
Bumbalo, T. S., and Plummer, L. J.:  Piperazine (Antepar) in the Treatment of Pinworm and Roundworm Infections , M. Clin. North American 41:575, 1947;.
15 +
Royer, A.:  Preliminary Report on a New Antioxyurite, Poquil , Canad. M.A.J. 74:297, 1956;.
16 +
Sawitz, W. G., and Karpinski, F. E.:  Treatment of Oxyuriasis with Pyrrovinyquinium Chloride (Poquil) , Am. J. Trop. Med. 3:538, 1956;.

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References

1 +
Birch, C. L., and Anast, B. P.:  The Changing Distribution of Helminthic Diseases in the United States , J.A.M.A. 164:121, 1957;.
2 +
Bumbalo, T. S., and Stiff, D. W.:  Roentgenologic Diagnosis of Roundworm Infection , New York J. Med. 57:3832, 1957;.
3 +
Brown, H. W.; Chan, K. F., and Hussey, K. L.:  Treatment of Enterobiasis and Ascariasis with Piperazine , J.A.M.A. 161:515, 1956;.
4 +
Miller, J. H.; Anthony, S. O.; Swartzwelder, J. C.; Frye, W. W., and Lampert, R.:  The Treatment of Enterobiasis with Dithiazanine , Am. J. Digest. Dis. (n.s.) 3:229, 1958;.
5 +
Bumbalo, T. S.; Plummer, L. J., and Warner, J. R.:  The Treatment of Enterobiasis in Children: A Comparative Study of Piperazine (Antepar) and Pyrvinium Chloride (Vanquin) , Am. J. Trop. Med. 7:212, 1958;.
6 +
Jenkins, M. E.:  Enterobiasis in Children: The Use of Zinc Oxide Ointment Locally as a Therapeutic Agent , J. Pediat. 50:714, 1957;.
7 +
Bumbalo, T. S.; Gustina, F. J., and Oleksiak, R. E.:  The Treatment of Enterobiasis with Thymyl-N-Isoamylcarbamate (Egressin) , J. Parasitol 39:166, 1953;.
8 +
Bumbalo, T. S.; Gustina, F. J., and Oleksiak, R. E.:  The Treatment of Pinworm Infection (Enterobiasis): A Comparative Study of 3 Oxyuricides , J. Pediat. 44:386, 1954;.
9 +
Bumbalo, T. S.; Plummer, L. J., and Warner, J. R.:  Treatment of Enterobiasis with One Oral Dose of Promethazine Hydrochloride , J.A.M.A. 164:1651, 1957;.
10 +
Bumbalo, T. S.; Gustina, F. J., and Oleksiak, R. E.:  The Treatment of Pinworm Infection with Papain , J. Pediat. 42:576, 1953;.
11 +
Cram, E. B.:  Studies on Oxyuricides: XXVIII. Summary and Conclusion , Am. J. Dis. Child. 65:46, 1943;.
12 +
Swartzwelder, J. C.; Frye, W. W.; Muhleison, J. P.; Miller, J. H., Lampert, R.; Chavarria, A. P.; Abadie, S. H.; Anthony, S. O., and Sappenfield, R. W.:  Dithiazanine: An Effective Broad-Spectrum Anthelmintic: Results of Therapy of Trichuriasis, Strongyloidiasis, Enterobiasis, Ascariasis, and Hookworm Infection , J.A.M.A. 165: 2063, 1957;.
13 +
Bumbalo, T. S., and Gustina, F. J.:  Scientific Exhibit: Treatment of Pinworm Infection in Children , Postgrad. Med. 14:83, 1953;.
14 +
Bumbalo, T. S., and Plummer, L. J.:  Piperazine (Antepar) in the Treatment of Pinworm and Roundworm Infections , M. Clin. North American 41:575, 1947;.
15 +
Royer, A.:  Preliminary Report on a New Antioxyurite, Poquil , Canad. M.A.J. 74:297, 1956;.
16 +
Sawitz, W. G., and Karpinski, F. E.:  Treatment of Oxyuriasis with Pyrrovinyquinium Chloride (Poquil) , Am. J. Trop. Med. 3:538, 1956;.

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