0
April 1960, Vol 99, No. 4 >
Article | April 1960

Primary Endocardial Fibroelastosis in Two Sisters FREE

S. T. WINTER, M.B.E., M.B., D.C.H.; W. S. MOSES, M.D.; N. J. COHEN, M.D.; J. M. NAFTALIN, M.B., D.P.H.
[+] Author Affiliations

Submitted for publication April 21, 1959.


AMA Am J Dis Child. 1960;99(4):529-533. doi:10.1001/archpedi.1960.02070030531016.
Text Size: A A A
Published online
Article
References
Comments

Endocardial fibroelastosis was first reported by Kreysig, in 1816, under the misnomer of fetal endocarditis.1 New concepts have developed in the understanding of this condition, especially since 1941. This term is now generally accepted as embracing various entities, including adult forms. Andersen and Kelly,2 in 1956, showed that many children with congenital heart disease develop endocardial fibroelastosis, apparently secondary to hemodynamic factors or anoxia in the malformed heart. A single group remains unassociated with other cardiac abnormalities, and this is termed "primary" endocardial fibroelastosis.3 The etiology of primary endocardial fibroelastosis is not certain, but it has been suggested that this lesion is a genetically determined developmental anomaly, possibly due to an enzymatic defect of the myocardium.1 The occurrence of primary endocardial fibroelastosis in siblings is rare. An accumulation of data on such familial cases might support the theory of a familial metabolic disorder, as well as

REFERENCES

1 +
Keith, J. D.; Rowe, R. D., and Vlad, P.: Heart Disease in Infancy and Childhood , New York, The Macmillan Company, 1958;.
2 +
Andersen, D. H., and Kelly, J.:  Endocardial Fibro-Elastosis: I. Endocardial Fibro-Elastosis Associated with Congenital Malformations of the Heart , Pediatrics 18:513, 1956;.
3 +
Kelly, J., and Andersen, D. H.:  Congenital Endocardial Fibro-Elastosis: II. A Clinical and Pathologic Investigation of Those Cases Without Associated Cardiac Malformations Including Report of 2 Familial Instances , Pediatrics 18:539, 1956;.
4 +
Ullrich, O.:  Angeborene Herzhypertrophie mit Endokardfibrose bei zwei eineiigen Partnern von männlichen Drillingen , Ztschr. menschl. Vererb.-u. Konstitutionslehre 21:585, 1938;.
5 +
Weinberg, T., and Himelfarb, A. J.:  Endocardial Fibro-Elastosis (So-Called Fetal Endocarditis) , Bull. Johns Hopkins Hosp. 72:299, 1943;.
6 +
Dordick, J. R.:  Diffuse Endocardial Fibrosis and Cardiac Hypertrophy in Infancy , Am. J. Clin. Path. 21:743, 1951;.
7 +
Still, W. J. S.:  Endocardial Fibrosis , Lancet 2:1261, 1954;.
8 +
Greaves, J. L.; Wilkins, P. S. W., and Pearson, S.:  Endocardial Fibroelastosis in Identical Twins , Arch. Dis. Childhood 29:447, 1954;.
9 +
Rosahn, P. D.:  Endocardial Fibroelastosis: Old and New Concepts , Bull. New York Acad. Med. 31:453, 1955;.
10 +
Gross, P.:  Concept of Fetal Endocarditis: General Review with Report of Illustrative Case , Arch. Path. 31:163, 1941;.
11 +
Black-Schaffer, B., and Turner, M. E.:  Hyperplastic Infantile Megacardia: A Form of "Idiopathic Hypertrophy" With or Without Endocardial Fibroelastosis and a Comment on Cardiac "Atrophy," Am. J. Path. 34:745, 1958;.
12 +
Still, W. J. S., and Boult, E. N.:  Electron Microscopy of Endocardial Fibroelastosis , Arch. Dis. Childhood 32:298, 1957;.
13 +
Lambert, E. C., and Vlad, P.:  Primary Endocardial Disease , Pediat. Clin. North America 5: 1057, 1958;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Keith, J. D.; Rowe, R. D., and Vlad, P.: Heart Disease in Infancy and Childhood , New York, The Macmillan Company, 1958;.
2 +
Andersen, D. H., and Kelly, J.:  Endocardial Fibro-Elastosis: I. Endocardial Fibro-Elastosis Associated with Congenital Malformations of the Heart , Pediatrics 18:513, 1956;.
3 +
Kelly, J., and Andersen, D. H.:  Congenital Endocardial Fibro-Elastosis: II. A Clinical and Pathologic Investigation of Those Cases Without Associated Cardiac Malformations Including Report of 2 Familial Instances , Pediatrics 18:539, 1956;.
4 +
Ullrich, O.:  Angeborene Herzhypertrophie mit Endokardfibrose bei zwei eineiigen Partnern von männlichen Drillingen , Ztschr. menschl. Vererb.-u. Konstitutionslehre 21:585, 1938;.
5 +
Weinberg, T., and Himelfarb, A. J.:  Endocardial Fibro-Elastosis (So-Called Fetal Endocarditis) , Bull. Johns Hopkins Hosp. 72:299, 1943;.
6 +
Dordick, J. R.:  Diffuse Endocardial Fibrosis and Cardiac Hypertrophy in Infancy , Am. J. Clin. Path. 21:743, 1951;.
7 +
Still, W. J. S.:  Endocardial Fibrosis , Lancet 2:1261, 1954;.
8 +
Greaves, J. L.; Wilkins, P. S. W., and Pearson, S.:  Endocardial Fibroelastosis in Identical Twins , Arch. Dis. Childhood 29:447, 1954;.
9 +
Rosahn, P. D.:  Endocardial Fibroelastosis: Old and New Concepts , Bull. New York Acad. Med. 31:453, 1955;.
10 +
Gross, P.:  Concept of Fetal Endocarditis: General Review with Report of Illustrative Case , Arch. Path. 31:163, 1941;.
11 +
Black-Schaffer, B., and Turner, M. E.:  Hyperplastic Infantile Megacardia: A Form of "Idiopathic Hypertrophy" With or Without Endocardial Fibroelastosis and a Comment on Cardiac "Atrophy," Am. J. Path. 34:745, 1958;.
12 +
Still, W. J. S., and Boult, E. N.:  Electron Microscopy of Endocardial Fibroelastosis , Arch. Dis. Childhood 32:298, 1957;.
13 +
Lambert, E. C., and Vlad, P.:  Primary Endocardial Disease , Pediat. Clin. North America 5: 1057, 1958;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems