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The Creatinine Excretion and Urine Volume of Premature Infants

AMA Am J Dis Child. 1960;99(4):507-515. doi:10.1001/archpedi.1960.02070030509013.
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The amount of urinary creatinine has been accepted as a reliable indicator of the daily urine volume of normal adults since Folin described the extremely consistent amount of creatinine excretion.1 Shortly thereafter, Amberg and Morrill2 reported that the creatinine excretion per kilogram of body weight by infants was less than half that of adults. Later, Marples and Levine3 studied six premature infants and reported small but inconsistent daily variations in the creatinine excretion. Marples4 found no upward trend of creatinine excretion with chronologic age during the first 2 months of life. Daniels and Hejinian5 found an increasing creatinine excretion between 2 and 7 months of age, while Catherwood and Stearns6 demonstrated that in full-term infants the urinary excretion of creatinine increased in a linear fashion with relation to body weight during the first year of life. From this they concluded that in full-term infants


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