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April 1960, Vol 99, No. 4 >
Article | April 1960

Hereditary Nephritis FREE

JAMES A. CHAPPELL, M.D.; WESTON M. KELSEY, M.D.
[+] Author Affiliations

Submitted for publication June 2, 1959.


AMA Am J Dis Child. 1960;99(4):401-407. doi:10.1001/archpedi.1960.02070030403001.
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Sporadic reports of nephritis occurring in siblings have appeared in the literature since the latter part of the 19th century.1-8 Recently it has been recognized that some types of nephritis might represent a hereditary disease. Alport1 first associated deafness with familial renal disease, in 1927. At the present time there are only 10 reported families manifesting this syndrome. The purpose of this paper is to briefly review the literature and to present two additional kindreds which have been found in the past year.

Report of Cases  Case 1 (P.).—A 7-year-old girl was referred to the North Carolina Baptist Hospital for evaluation of "Bright's disease." The child had had episodesn of "swelling up and passing dark water" since early infancy. These episodes occurred four to five times a year. Because there was an extensive family history of "Bright's disease," the parents were aware of symptoms of renal disease and

REFERENCES

1 +
Alport, A. C.:  Hereditary Familial Congenital Haemorrhagic Nephritis , Brit. M.J. 1:504, 1927;.
2 +
Mitchell, A. G.:  Nephrosclerosis (Chronic Interstitial Nephritis) in Childhood, with Special Reference to Renal Rickets , Am. J. Dis. Child. 40:101, 345, 1930;.
3 +
Clark, N. S.:  Familial Renal Insufficiency , Arch. Dis. Childhood 26:351, 1951;.
4 +
Perkoff, G. T.; Stephens, F. E.; Dolowitz, D. A., and Tyler, F. H.:  A Clinical Study of Hereditary Interstitial Pyelonephritis , A.M.A. Arch. Int. Med. 88:191, 1951;.
5 +
Sturtz, G. S., and Burke, E. C.:  Hereditary Hematuria, Nephropathy and Deafness: Preliminary Report , New England J. Med. 254:1123, 1956;.
6 +
Goldbloom, R. B.; Fraser, F. C.; Waugh, D.; Aronovitch, M., and Wiglesworth, F. W.:  Hereditary Renal Disease Associated with Nerve Deafness and Ocular Lesions , Pediatrics 20:241, 1957;.
7 +
Sohar, E.:  Renal Disease, Inner Ear Deafness, and Ocular Changes , A.M.A. Arch. Int. Med. 97: 627, 1956;.
8 +
Reyersbach, G. C., and Butler, A. M.:  Congenital Hereditary Hematuria , New England J. Med. 251:377, 1954;.
9 +
Perkoff, G. T.; Nugent, C. A., Jr.; Dolowitz, D. A.; Stephens, F. E.; Carnes, W. H., and Tyler, F. H.:  A Follow-Up Study of Hereditary Chronic Nephritis , A.M.A Arch. Int. Med. 102:733, 1958;.

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References

1 +
Alport, A. C.:  Hereditary Familial Congenital Haemorrhagic Nephritis , Brit. M.J. 1:504, 1927;.
2 +
Mitchell, A. G.:  Nephrosclerosis (Chronic Interstitial Nephritis) in Childhood, with Special Reference to Renal Rickets , Am. J. Dis. Child. 40:101, 345, 1930;.
3 +
Clark, N. S.:  Familial Renal Insufficiency , Arch. Dis. Childhood 26:351, 1951;.
4 +
Perkoff, G. T.; Stephens, F. E.; Dolowitz, D. A., and Tyler, F. H.:  A Clinical Study of Hereditary Interstitial Pyelonephritis , A.M.A. Arch. Int. Med. 88:191, 1951;.
5 +
Sturtz, G. S., and Burke, E. C.:  Hereditary Hematuria, Nephropathy and Deafness: Preliminary Report , New England J. Med. 254:1123, 1956;.
6 +
Goldbloom, R. B.; Fraser, F. C.; Waugh, D.; Aronovitch, M., and Wiglesworth, F. W.:  Hereditary Renal Disease Associated with Nerve Deafness and Ocular Lesions , Pediatrics 20:241, 1957;.
7 +
Sohar, E.:  Renal Disease, Inner Ear Deafness, and Ocular Changes , A.M.A. Arch. Int. Med. 97: 627, 1956;.
8 +
Reyersbach, G. C., and Butler, A. M.:  Congenital Hereditary Hematuria , New England J. Med. 251:377, 1954;.
9 +
Perkoff, G. T.; Nugent, C. A., Jr.; Dolowitz, D. A.; Stephens, F. E.; Carnes, W. H., and Tyler, F. H.:  A Follow-Up Study of Hereditary Chronic Nephritis , A.M.A Arch. Int. Med. 102:733, 1958;.

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