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Combined Familial Proteinuria and Hypercholesteremia

AMA Am J Dis Child. 1960;99(3):261-275. doi:10.1001/archpedi.1960.02070030263003.
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In the course of conducting an investigation of a family group showing proteinuria and hypercholesteremia but without evidence of nephrosis or other disease,* data were obtained showing the presence of two concurrent but nevertheless independent hereditary traits: (a) proteinuria, with an associated abnormality of the serum protein fractions, and (b) hypercholesteremia, also associated with a distinct abnormality of the serum protein fractions. A review of the literature failed to reveal any previous reports of either the association of abnormal concentrations of serum protein fractions with familial proteinuria or the simultaneous occurrence in the same subjects of familial proteinuria and familial hypercholesteremia. The results of a study of two generations of a family group demonstrating these findings are reported.

Material and Methods  The patients comprising this study consisted of 16 persons of two generations of one family line.

Mode of Recognition and Chronological Sequence of Investigation  Seven of the subjects, all


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