Histopathological studies of tissue obtained from fatal cases of meconium ileus and cystic fibrosis of the pancreas have clearly established the structural changes associated with these diseases.1 A considerable mass of data has been accumulated demonstrating the morphological spectrum of changes in the evolution of these disorders. However, such observations have not elucidated the etiology and pathogenesis of these conditions. In an attempt to gain further insight into the pathogenetic mechanisms involved, characteristically involved human tissues have been subjected to histochemical study. In addition to the histochemical analysis of diseased and control human tissues, parallel observations were carried out in animals under chronic parasympathetic stimulation. The experimental animals studies were based on the original claims of Farber that parasympathetic stimulation could provoke pancreatic changes similar to cystic fibrosis.
Materials and Methods
Postmortem examination within one to four hours after death was performed in three cases of meconium ileus and