Myocardial Changes in Lead Poisoning FREE

TILDE S. KLINE, M.D.

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Submitted for publication July 20, 1959.

This work was supported by the Wilmette Myocarditis Research Fund.

AMA Am J Dis Child. 1960;99(1):48-54. doi:10.1001/archpedi.1960.02070030050009.

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ABSTRACT

ABSTRACT | REFERENCES

Angina pectoris in patients with chronic lead poisoning has been mentioned briefly in the literature since 1829, when Andral, as quoted by Hirschfeld,⁵ described symptoms of palpitation, dyspnea, and generalized precordial discomfort in such patients. Hirschfeld,⁵ in 1926, coined the term "angina pectoris saturnina" and believed that this was the result of spasm of the coronary vessels brought about by the effects of lead. The patients whom he described were between 20 and 30 years old. There were no autopsies. Sporadic cases appeared in the literature since that time (Sessa and Guarino¹¹). More recently, Read and Williams⁸ studied a case of lead poisoning in which the patient had complained of substernal pain. The electrocardiograph revealed marked depression of the conduction system and T-wave abnormalities. The patient subsequently recovered, and thereafter his electrocardiographs were within normal limits. In two other patients with plumbism Read and Williams

REFERENCES

ABSTRACT | REFERENCES

Blackman, S. S., Jr.: Intranuclear Inclusion Bodies in the Kidney and Liver Caused by Lead Poisoning , Bull. Johns Hopkins Hosp. 58:384-403, 1936;.

Blackman, S. S., Jr.: Lesions of Lead Encephalitis in Children , Bull. Johns Hopkins Hosp. 61:1-61, 1937;.

Coppoletta, J. M., and Wolbach, S. B.: Body Length and Organ Weights of Infants and Children: Study of Body Length and Normal Weights of More Important Vital Organs of Body Between Birth and 12 Years of Age , Am. J. Path. 9:55-70, 1933;.

Greenberg M.; Jacobziner, H.; McLaughlin, M. C.; Fuerst, H. T., and Pelliteri, O.: A Study of Pica in Relation to Lead Poisoning , Pediatrics 22:756-760, 1958;.

Hirschfeld, E.: Angina Pectoris Saturnina , Ztschr. klin. Med. 104:698-712, 1926;.

Hughes, J. P., and Kehoe, R. A.: Lead Poisoning , in Tice, F., Practice of Medicine , Vol. 8, Hagerstown, Md., W. F. Prior Co., Inc., 1957;, pp. 59-74.

Nelson, W. E.: Textbook of Pediatrics , Ed. 6, Philadelphia, W. B. Saunders Company, 1954;, p. 821.

Read, J. L., and Williams, J. P.: Lead Myocarditis: Report of a Case , Am. Heart J. 44:797-802, 1952;.

Rössle, R.: Über wenig beachtete Formen der Entzündung von Parenchymen und ihre Beziehung zur Organsklerosen , Verhandl. deutsch. path. Gesellsch. 27:152, 1934;.

Saphir, O.; Stryzak, D., and Ohringer, L.: Hypersensitivity Changes in the Coronary Arteries of Rabbits and Their Relationship to Arteriosclerosis , Lab. Invest. 7:434-444, 1958;.

Sessa, T., and Guarino, A.: A Case of Saturnine Myocardiopathy: Diagnostic and Medico-Legal Aspects , Folia med. 40:273-299, 1957;.

Wachstein, M.: Studies on Inclusion Bodies , Am. J. Clin. Path. 19:608-614, 1949;.

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