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September 1959, Vol 98, No. 3 >
Article | September 1959

Diabetes Mellitus or the Prediabetic State in the Mother and the Neonate:  Effect on the Homeostasis of Calcium, Phosphorus, and Some Other Electrolytes in the Neonate on the First Day of Life FREE

I. F. GITTLEMAN, M.D.; J. B. PINCUS, M.D.; E. SCHMERTZLER, B.S.; F. ANNECCHIARICO
[+] Author Affiliations

Submitted for publication Dec. 20, 1958.

Supported by U. S. Public Health Service Grant A-126 (C5) (C6) and Ross Laboratories, Columbus, Ohio.

A mother was considered in the prediabetic state by the internist and obstetrician when her glucose tolerance curve was diabetic-like in one or more pregnancies.


AMA Am J Dis Child. 1959;98(3):342-349. doi:10.1001/archpedi.1959.02070020344007.
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References
Comments

In a previous publication we noted that the incidence of hypocalcemia on the first day of life was significantly higher in infants born to mothers who had abnormal pregnancies, labor, or both.1 In this group, diabetes mellitus in the mother played a prominent role.

We therefore investigated the incidence of hypocalcemia on the. first day of life in infants born to diabetic mothers and to mothers who were found to have a prediabetic state during pregnancy.* We also made simultaneous observations on some other constituents of the blood.

Patient Material and Methods  The infants were divided into two groups. Group I consisted of 22 infants born to diabetic mothers whose diabetic state had been recognized for periods varying between 1 and 18 years. All mothers of this group of infants received insulin, but no other hormones. All but two infants were delivered by cesarean section. Group II contained 36

REFERENCES

1 +
Gittleman, I. F.; Pincus, J. B.; Schmerzler, E., and Saito, M.:  Hypocalcemia Occurring on the First Day of Life in Mature and Premature Infants , Pediatrics 18:721, 1956;.
2 +
Sobel, A. E., and Sobel, B. A.:  Microestimation of Calcium in Serum , J. Biol. Chem. 129:721, 1939;.
3 +
Sobel, A. E.:  Microestimation of Inorganic Phosphate , Indust. & Engin. Chem. (Analyt. Ed.) 17:242, 1945;.
4 +
Natelson, S.:  Routine Use of Ultramicro Methods in the Clinical Laboratory , Am. J. Clin. Path. 21:1153, 1951;.
5 +
Natelson, S.:  Routine of the Perkin-Elmer Flame Photometer in the Clinical Laboratory , Am. J. Clin. Path. 20:463, 1950;.
6 +
Kopp-Natelson Micro-Gasometer, Model 511, Kopp Scientific Instruments, Inc., 15 Park St., Springfield 5, Mass.
7 +
Sobel, A. E., and Hanok, A.:  Ultramicro Quantitative Analysis in Clinical Laboratories , Microchemie 39:51, 1952;.
8 +
Schales, O., and Schales, S. S.:  Simple and Accurate Method for Determination of Chloride in Biological Fluids , J. Biol. Chem. 140:879, 1941;.
9 +
Sobel, A. E., and Kraus, G.: Micro Modification of Folin-Wu, presented at the International Pediatric Congress, 1947.
10 +
Willi, H.:  Die Neugeborenenspasmophilie , Monatschr. Kinderh. 80:309, 1939;.
11 +
Dodd, K., and Rapoport, S.:  Hypocalcemia in the Neonatal Period , Am. J. Dis. Child. 78:537, 1949;.
12 +
Bakwin, H.:  Pathogenesis of Tetany of the New-Born , Am. J. Dis. Child. 54:1211, 1937;.
13 +
Gardner, L. I.; MacLachlan, E. H.; Pick, W.; Terry, M. L., and Butler, A. M.:  Etiologic Factors in Tetany of Newly Born Infants , Pediatrics 5:228, 1950;.
14 +
Gittleman, I. F., and Pincus, J. B.:  Influence of Diet on the Occurrence of Hyperphosphatemia and Hypocalcemia in the Newborn Infant , Pediatrics 8:778, 1951;.
15 +
Zetterström, R., and Arnold, R. G.:  Impaired Calcium-Phosphate Homeostasis in Newborn Infants of Diabetic Mothers , Acta paediat. 47:107, 112, 1958;.
16 +
Craig, W. S.:  Clinical Signs of Neonatal Tetany, with Especial Reference to Their Oc currence in Newborn Babies of Diabetic Mothers , Pediatrics 22:297, 1958;.
17 +
Gittleman, I. F., and Pincus, J. B.:  Blood Sugar and Citric Acid Levels in Newborn Infants , Pediatrics 9:38, 1952;.
18 +
Lowrey, G. H.; Graham, B. D., and Tsao, M. U.:  Chemical Homeostasis in the Newborn Infants of Diabetic Mothers , Pediatrics 13:527, 1954;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Gittleman, I. F.; Pincus, J. B.; Schmerzler, E., and Saito, M.:  Hypocalcemia Occurring on the First Day of Life in Mature and Premature Infants , Pediatrics 18:721, 1956;.
2 +
Sobel, A. E., and Sobel, B. A.:  Microestimation of Calcium in Serum , J. Biol. Chem. 129:721, 1939;.
3 +
Sobel, A. E.:  Microestimation of Inorganic Phosphate , Indust. & Engin. Chem. (Analyt. Ed.) 17:242, 1945;.
4 +
Natelson, S.:  Routine Use of Ultramicro Methods in the Clinical Laboratory , Am. J. Clin. Path. 21:1153, 1951;.
5 +
Natelson, S.:  Routine of the Perkin-Elmer Flame Photometer in the Clinical Laboratory , Am. J. Clin. Path. 20:463, 1950;.
6 +
Kopp-Natelson Micro-Gasometer, Model 511, Kopp Scientific Instruments, Inc., 15 Park St., Springfield 5, Mass.
7 +
Sobel, A. E., and Hanok, A.:  Ultramicro Quantitative Analysis in Clinical Laboratories , Microchemie 39:51, 1952;.
8 +
Schales, O., and Schales, S. S.:  Simple and Accurate Method for Determination of Chloride in Biological Fluids , J. Biol. Chem. 140:879, 1941;.
9 +
Sobel, A. E., and Kraus, G.: Micro Modification of Folin-Wu, presented at the International Pediatric Congress, 1947.
10 +
Willi, H.:  Die Neugeborenenspasmophilie , Monatschr. Kinderh. 80:309, 1939;.
11 +
Dodd, K., and Rapoport, S.:  Hypocalcemia in the Neonatal Period , Am. J. Dis. Child. 78:537, 1949;.
12 +
Bakwin, H.:  Pathogenesis of Tetany of the New-Born , Am. J. Dis. Child. 54:1211, 1937;.
13 +
Gardner, L. I.; MacLachlan, E. H.; Pick, W.; Terry, M. L., and Butler, A. M.:  Etiologic Factors in Tetany of Newly Born Infants , Pediatrics 5:228, 1950;.
14 +
Gittleman, I. F., and Pincus, J. B.:  Influence of Diet on the Occurrence of Hyperphosphatemia and Hypocalcemia in the Newborn Infant , Pediatrics 8:778, 1951;.
15 +
Zetterström, R., and Arnold, R. G.:  Impaired Calcium-Phosphate Homeostasis in Newborn Infants of Diabetic Mothers , Acta paediat. 47:107, 112, 1958;.
16 +
Craig, W. S.:  Clinical Signs of Neonatal Tetany, with Especial Reference to Their Oc currence in Newborn Babies of Diabetic Mothers , Pediatrics 22:297, 1958;.
17 +
Gittleman, I. F., and Pincus, J. B.:  Blood Sugar and Citric Acid Levels in Newborn Infants , Pediatrics 9:38, 1952;.
18 +
Lowrey, G. H.; Graham, B. D., and Tsao, M. U.:  Chemical Homeostasis in the Newborn Infants of Diabetic Mothers , Pediatrics 13:527, 1954;.

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