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September 1959, Vol 98, No. 3 >
Article | September 1959

Testosterone-Induced Remission in Aplastic Anemia FREE

NASROLLAH T. SHAHIDI, M.D.; LOUIS K. DIAMOND, M.D.
[+] Author Affiliations

Submitted for publication June 12, 1959.

Presented in condensed form at the meeting of the American Pediatric Society, Buck Hill Falls, Pa., May 8, 1959.

This investigation was supported in part by a grant (H 2405) from the National Institutes of Health and by the John A. Hartford Foundation.


AMA Am J Dis Child. 1959;98(3):293-302. doi:10.1001/archpedi.1959.02070020295002.
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Introduction  The treatment of aplastic anemia in childhood and adolescence has been one of the most hopeless and discouraging problems in the practice of pediatrics. In addition it has become a very worrisome problem since it seems to us that its incidence is increasing steadily. Review of the cases of aplastic anemia seen at the Children's Hospital during the past 20 years revealed that of 40 patients only 2 had a spontaneous remission and only one survived after four years. The others died from either generalized infection or hemorrhage. All therapeutic efforts have been uniformly unsuccessful. Transfusions, vitamin preparations, splenectomy, corticosteroids, and corticotropin have been tried singly or in combination, to no avail.The aim of this paper is to describe a new approach to the therapy of this serious disease. For the past 16 months in addition to corticosteroid therapy and transfusion of platelets, fresh blood, and stored blood

REFERENCES

1 +
Kennedy, B. J., and Nathanson, I. T.:  Effects of Intensive Sex Steroid Hormone Therapy in Advanced Breast Cancer , J.A.M.A. 152:1135, 1953;.
2 +
Pringle, T. C., Jr., and Gardner, F. H.:  Treatment of Myeloid Metaplasia with Testosterone , Clin. Res. 7:210, 1959;.
3 +
Gordon, A. S., and Charipper, H. A.:  The Endocrine System and Hemopoiesis , Ann. New York Acad. Sc. 48:615, 1947;.
4 +
Necheles, T. F.; Weinstein, I. M., and LeRoy, G. V.:  Radioactive Sodium Chromate for the Study of Survival of Red Blood Cells , J. Lab. & Clin. Med. 42:358, 1953;.
5 +
Kennedy, B. J.; Tibbetts, D. M.; Nathanson, I. T., and Aub, J. C.:  Hypercalcemia, a Complication of Hormone Therapy of Advanced Breast Cancer , Cancer Res. 13:445, 1953;.
6 +
Butler, A. M.; Talbot, N. B., and MacLachlan, E. A.:  Effect of Testosterone Therapy on Concentration of Potassium in Serum , Proc. Soc. Exper. Biol. & Med. 51:378, 1942;.
7 +
Tyslowitz, R., and Dingemanse, E.:  Effect of Large Doses of Estrogens on the Blood Picture of Dogs , Endocrinology 29:817, 1941;.
8 +
Tyslowitz, R., and Hartman, C. G.:  Influence of Large Doses of Estrogens on the Blood Picture of Rhesus Monkeys (Macaca Mulatta) , Endocrinology 29:349, 1941;.
9 +
Vollmer, E. P., and Gordon, A. S.:  Effect of Sex and Gonadotropic Hormones upon the Blood Picture of the Rat , Endocrinology 29:828, 1941;.
10 +
Gottschalk, R. G., and Furth, J.:  Polycythemia with Features of Cushing's Syndrome Produced by Luteomas , Acta haemat. 5:100, 1951;.
11 +
Kennedy, M. D.:  Fluoxymesterone in the Treatment of Advanced Breast Cancer , Cancer 10:813, 1957;.
12 +
Wolff, J. A.:  Anemias Caused by Infection and Toxins: Idiopathic Aplastic Anemia and Anemia Caused by Renal Disease , Pediat. Clin. North America , p. 469, (May) , 1957;.
13 +
Bomford, R. R., and Rhoads, C. P.:  Refractory Anemia , Quart. J. Med. 10:175, 1941;.
14 +
Barker, W. H.:  Excretion of Bile Pigment and Hepatic Function in Disease of the Blood , Arch. Int. Med. 62:222, 1938;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Kennedy, B. J., and Nathanson, I. T.:  Effects of Intensive Sex Steroid Hormone Therapy in Advanced Breast Cancer , J.A.M.A. 152:1135, 1953;.
2 +
Pringle, T. C., Jr., and Gardner, F. H.:  Treatment of Myeloid Metaplasia with Testosterone , Clin. Res. 7:210, 1959;.
3 +
Gordon, A. S., and Charipper, H. A.:  The Endocrine System and Hemopoiesis , Ann. New York Acad. Sc. 48:615, 1947;.
4 +
Necheles, T. F.; Weinstein, I. M., and LeRoy, G. V.:  Radioactive Sodium Chromate for the Study of Survival of Red Blood Cells , J. Lab. & Clin. Med. 42:358, 1953;.
5 +
Kennedy, B. J.; Tibbetts, D. M.; Nathanson, I. T., and Aub, J. C.:  Hypercalcemia, a Complication of Hormone Therapy of Advanced Breast Cancer , Cancer Res. 13:445, 1953;.
6 +
Butler, A. M.; Talbot, N. B., and MacLachlan, E. A.:  Effect of Testosterone Therapy on Concentration of Potassium in Serum , Proc. Soc. Exper. Biol. & Med. 51:378, 1942;.
7 +
Tyslowitz, R., and Dingemanse, E.:  Effect of Large Doses of Estrogens on the Blood Picture of Dogs , Endocrinology 29:817, 1941;.
8 +
Tyslowitz, R., and Hartman, C. G.:  Influence of Large Doses of Estrogens on the Blood Picture of Rhesus Monkeys (Macaca Mulatta) , Endocrinology 29:349, 1941;.
9 +
Vollmer, E. P., and Gordon, A. S.:  Effect of Sex and Gonadotropic Hormones upon the Blood Picture of the Rat , Endocrinology 29:828, 1941;.
10 +
Gottschalk, R. G., and Furth, J.:  Polycythemia with Features of Cushing's Syndrome Produced by Luteomas , Acta haemat. 5:100, 1951;.
11 +
Kennedy, M. D.:  Fluoxymesterone in the Treatment of Advanced Breast Cancer , Cancer 10:813, 1957;.
12 +
Wolff, J. A.:  Anemias Caused by Infection and Toxins: Idiopathic Aplastic Anemia and Anemia Caused by Renal Disease , Pediat. Clin. North America , p. 469, (May) , 1957;.
13 +
Bomford, R. R., and Rhoads, C. P.:  Refractory Anemia , Quart. J. Med. 10:175, 1941;.
14 +
Barker, W. H.:  Excretion of Bile Pigment and Hepatic Function in Disease of the Blood , Arch. Int. Med. 62:222, 1938;.

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