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August 1959, Vol 98, No. 2 >
Article | August 1959

Observations on a Baby Born to a Mother with Congenital Adrenal Hyperplasia FREE

ZVI LARON, M.D.
[+] Author Affiliations

Submitted for publication Dec. 4, 1958.


AMA Am J Dis Child. 1959;98(2):162-165. doi:10.1001/archpedi.1959.02070020164004.
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Comments

Since the introduction of cortisone as treatment of the adrenogenital syndrome by Wilkins et al.1 only three women with congenital adrenal hyperplasia, including one from this hospital, have been reported to have given birth to a live baby.2-4

Considering the problems presented by the baby of a mother with the adrenogenital syndrome, a disease generally considered inheritable,5 and in particular the possible damage to the fetus by prolonged administration of cortisone to the pregnant mother, it seems justified to present the metabolic and endocrine studies performed on such a baby born in our hospital.

Report of Case  The patient's mother came under medical attention at the age of 16 years, because of hirsutism and amenorrhea, and was found to have a very enlarged clitoris and a urogenital sinus. She had had pubic and axillary hair since the age of 3 years. She was considered to have female

REFERENCES

1 +
Wilkins, L.; Lewis, R. A.; Klein, R., and Rosemberg, E.:  The Suppression of Androgen Secretion by Cortisone in a Case of Congenital Adrenal Hyperplasia , Bull. Johns Hopkins Hosp. 86:249, 1950;.
2 +
Yamashita, T., and Kozakae, F.:  Pregnancy and Delivery at Term by Long Term Cortisone Treatment of a Congenital Adrenocortical Hyperplasia , Endocrinologia Japonica 3:176, 1956;.
3 +
Wilson, R. B., and Keating, F. R., Jr.:  Pregnancy Following Treatment of Congenital Adrenal Hyperplasia with Cortisone , Am. J. Obst. & Gynec. 76:388, 1958;.
4 +
Gans, F., and Ser, I.: Normal Pregnancy and Delivery in Female Pseudohermaphroditism, Acta endocrinol., to be published.
5 +
Childs, B.:  Genetics in Pediatric Disease , Am. J. Med. Sc. 228:680, 1954;.
6 +
Ser, I.:  About a Case of Feminine Pseudohermaphroditism , Dapim Refuiim 16:3, 1955;.
7 +
Childs, B.; Grumbach, M. M., and Van Wyk, J. J.:  Virilizing Adrenal Hyperplasia; A Genetic and Hormonal Study , J. Clin. Invest. 35:213, 1956;.
8 +
Money, J.: Doctoral Dissertation, Cambridge, Mass., Harvard University Library, 1952, p. 43; cited by Childs.5
9 +
Fraser, F. C., and Fainstat, T. D.:  Production of Congenital Defects in the Offspring of Pregnant Mice , Pediatrics 8:527, 1951;.
10 +
Ingalls, T. H., and Curley, F. J.:  The Relation of Hydrocortisone Injections to Cleft Palate in Mice , New England J. Med. 256:1035, 1957;.
11 +
Harris, J. W., and Ross, J. P.:  Cortisone Therapy in Early Pregnancy: Relation to Cleft Palate , Lancet 1:1045, 1956;.
12 +
Doig, R. K., and Coltman, O. McK.:  Cleft Palate Following Cortisone Therapy in Early Pregnancy , Lancet 2:730, 1956;.
13 +
Baulieu, E. E.; Bricaire, H., and Jayle, M. F.:  Lack of Secretion of 17-Hydrocorticosteroids in a Pregnant Woman with Addison's Disease , J. Clin. Endocrinol. 16:690, 1956;.
14 +
Morgan, J. E., and Reyes, C. T.:  The Association of Acute Lymphatic Leukemia and Pregnancy , Obst. & Gynec. 8:642, 1956;.
15 +
Klein, R.:  Serum Corticoid Response to ACTH in Infants Age 3 Days , in Adrenal Function in Infants and Children: Report of the 13th M. & R. Pediatric Research Conference (1954) Columbus, Ohio, 1955;, p. 31.
16 +
Klein, R.:  Adrenocortical Control of Sodium and Potassium Excretion in the Newborn Period , J. Clin. Invest. 30:318, 1951;.

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References

1 +
Wilkins, L.; Lewis, R. A.; Klein, R., and Rosemberg, E.:  The Suppression of Androgen Secretion by Cortisone in a Case of Congenital Adrenal Hyperplasia , Bull. Johns Hopkins Hosp. 86:249, 1950;.
2 +
Yamashita, T., and Kozakae, F.:  Pregnancy and Delivery at Term by Long Term Cortisone Treatment of a Congenital Adrenocortical Hyperplasia , Endocrinologia Japonica 3:176, 1956;.
3 +
Wilson, R. B., and Keating, F. R., Jr.:  Pregnancy Following Treatment of Congenital Adrenal Hyperplasia with Cortisone , Am. J. Obst. & Gynec. 76:388, 1958;.
4 +
Gans, F., and Ser, I.: Normal Pregnancy and Delivery in Female Pseudohermaphroditism, Acta endocrinol., to be published.
5 +
Childs, B.:  Genetics in Pediatric Disease , Am. J. Med. Sc. 228:680, 1954;.
6 +
Ser, I.:  About a Case of Feminine Pseudohermaphroditism , Dapim Refuiim 16:3, 1955;.
7 +
Childs, B.; Grumbach, M. M., and Van Wyk, J. J.:  Virilizing Adrenal Hyperplasia; A Genetic and Hormonal Study , J. Clin. Invest. 35:213, 1956;.
8 +
Money, J.: Doctoral Dissertation, Cambridge, Mass., Harvard University Library, 1952, p. 43; cited by Childs.5
9 +
Fraser, F. C., and Fainstat, T. D.:  Production of Congenital Defects in the Offspring of Pregnant Mice , Pediatrics 8:527, 1951;.
10 +
Ingalls, T. H., and Curley, F. J.:  The Relation of Hydrocortisone Injections to Cleft Palate in Mice , New England J. Med. 256:1035, 1957;.
11 +
Harris, J. W., and Ross, J. P.:  Cortisone Therapy in Early Pregnancy: Relation to Cleft Palate , Lancet 1:1045, 1956;.
12 +
Doig, R. K., and Coltman, O. McK.:  Cleft Palate Following Cortisone Therapy in Early Pregnancy , Lancet 2:730, 1956;.
13 +
Baulieu, E. E.; Bricaire, H., and Jayle, M. F.:  Lack of Secretion of 17-Hydrocorticosteroids in a Pregnant Woman with Addison's Disease , J. Clin. Endocrinol. 16:690, 1956;.
14 +
Morgan, J. E., and Reyes, C. T.:  The Association of Acute Lymphatic Leukemia and Pregnancy , Obst. & Gynec. 8:642, 1956;.
15 +
Klein, R.:  Serum Corticoid Response to ACTH in Infants Age 3 Days , in Adrenal Function in Infants and Children: Report of the 13th M. & R. Pediatric Research Conference (1954) Columbus, Ohio, 1955;, p. 31.
16 +
Klein, R.:  Adrenocortical Control of Sodium and Potassium Excretion in the Newborn Period , J. Clin. Invest. 30:318, 1951;.

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