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August 1959, Vol 98, No. 2 >
Article | August 1959

Residual Encephalopathy Following Roseola Infantum FREE

RICHARD C. BURNSTINE, M.D.; RICHMOND S. PAINE, M.D.
[+] Author Affiliations

Submitted for publication Jan. 29, 1959.


AMA Am J Dis Child. 1959;98(2):144-152. doi:10.1001/archpedi.1959.02070020146002.
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Introduction  Roseola infantum, first described by Zahorsky1 in 1913, is generally considered a benign disease; indeed, Kempe2 noted there are no reported fatalities. Serious sequelae are usually stated to be virtually nonexistent. However, the possibility has been suggested in a comprehensive view of the subject,3 that some of the sudden deaths in infancy may be caused by roseola. No clear instances of this have been reported, no doubt owing to the difficulties of making a positive identification of the disease in the preeruptive stage and the inability to isolate the virus in tissue culture.Roseola infantum is the commonest exanthem under the age of 2 years, and infection is perhaps almost universal before the age of 5 years.3 The disease is characterized by the relative absence of prefebrile prodromata, an abrupt onset, and a rapid temperature rise. Irritibility and listlessness are variable; the patient is usually

REFERENCES

1 +
Zahorsky, J.:  Roseola Infantum , J. A. M. A. 61:1446, 1913;.
2 +
Kempe, C. H.; Shaw, E. B.; Jackson, J. R., and Silver, H. K.:  Studies on the Etiology of Exanthem Subitum , J. Pediat. 37:561, 1950;.
3 +
Berenberg, W.; Wright, S., and Janeway, C. A.:  Roseola Infantum (Exanthem Subitum) , New England J. Med. 241:253, 1949;.
4 +
Letchner, A.:  Roseola Infantum: Review of 50 Cases , Lancet 2:1163, 1955;.
5 +
Möller, K. L.:  Exanthema Subitum and Febrile Convulsions , Acta paediat. 45:534, 1946;.
6 +
Holliday, P. B., Jr.:  Pre-Eruptive Neurological Complications of the Common Contagious Diseases—Rubella, Rubeola, Roseola, and Varicella , J. Pediat. 36:185, 1950;.
7 +
Windorfer, A.:  Das Dreitagefieber—Exanthem der kleinen Kinder, Exanthema subitum , Deutsche med. Wchnschr. 70:1201, 1954;.
8 +
Rosenblum, J.:  Roseola Infantum (Exanthema Subitum) Complicated by Hemiplegia , Am. J. Dis. Child. 69:234, 1945;.
9 +
Posson, D. D.:  Exanthem Subitum (Roseola Infantum) Complicated by Prolonged Convulsions and Hemiplegia , J. Pediat. 35:235, 1949;.
10 +
Friedman, J. H.; Golomb, J., and Aronson, L.:  Hemiplegia Associated with Roseola Infantum (Exanthem Subitum) , New York J. Med. 50:1749, 1950;.
11 +
del Mundo, F.; Cordero, L. S., and Rodriguez, S.:  Pre-Eruptive Roseola Encephalitis: A Report of 2 Cases , J. Philippine M. A. 31:622, 1955;.
12 +
Glanzmann, E., cited by Windorfer.7

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Zahorsky, J.:  Roseola Infantum , J. A. M. A. 61:1446, 1913;.
2 +
Kempe, C. H.; Shaw, E. B.; Jackson, J. R., and Silver, H. K.:  Studies on the Etiology of Exanthem Subitum , J. Pediat. 37:561, 1950;.
3 +
Berenberg, W.; Wright, S., and Janeway, C. A.:  Roseola Infantum (Exanthem Subitum) , New England J. Med. 241:253, 1949;.
4 +
Letchner, A.:  Roseola Infantum: Review of 50 Cases , Lancet 2:1163, 1955;.
5 +
Möller, K. L.:  Exanthema Subitum and Febrile Convulsions , Acta paediat. 45:534, 1946;.
6 +
Holliday, P. B., Jr.:  Pre-Eruptive Neurological Complications of the Common Contagious Diseases—Rubella, Rubeola, Roseola, and Varicella , J. Pediat. 36:185, 1950;.
7 +
Windorfer, A.:  Das Dreitagefieber—Exanthem der kleinen Kinder, Exanthema subitum , Deutsche med. Wchnschr. 70:1201, 1954;.
8 +
Rosenblum, J.:  Roseola Infantum (Exanthema Subitum) Complicated by Hemiplegia , Am. J. Dis. Child. 69:234, 1945;.
9 +
Posson, D. D.:  Exanthem Subitum (Roseola Infantum) Complicated by Prolonged Convulsions and Hemiplegia , J. Pediat. 35:235, 1949;.
10 +
Friedman, J. H.; Golomb, J., and Aronson, L.:  Hemiplegia Associated with Roseola Infantum (Exanthem Subitum) , New York J. Med. 50:1749, 1950;.
11 +
del Mundo, F.; Cordero, L. S., and Rodriguez, S.:  Pre-Eruptive Roseola Encephalitis: A Report of 2 Cases , J. Philippine M. A. 31:622, 1955;.
12 +
Glanzmann, E., cited by Windorfer.7

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