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May 1959, Vol 97, No. 5_PART_II >
Article | May 1959

Studies on the Brain Ganglioside Strandin in Normal Brain and in Tay-Sachs' Disease FREE

JORDI FOLCH-PI, M.D.; MARJORIE LEES, Ph.D.
AMA Am J Dis Child. 1959;97(5_PART_II):730-738. doi:10.1001/archpedi.1959.02070010732012.
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Since our results bearing directly on TaySachs' disease are few and mainly of a confirmatory nature, it would seem that the best contribution that we can make to this Symposium is to report in some detail our own work on the brain ganglioside, strandin. This will constitute the bulk of the discussion and will be followed by the presentation of the results of the analyses of two brains of patients with Tay-Sachs' disease.

Strandin1 was reported originally as a complex lipide which had been isolated from gray matter by three different methods. Its name was chosen because, when recovered from water solutions by drying, strandin was obtained as a residue of long, glistening, birefringent strands. It was readily soluble in water as an undialyzable solute which was homogeneous in the electrophoretic field over a wide pH range. By ultracentrifugation it showed a major component which accounted for 80% of

REFERENCES

1 +
Folch, J.; Arsove, S., and Meath, J. A.:  Isolation of Brain Strandin, A New Type of Large Molecule Tissue Component , J. Biol. Chem. 191:819-831, 1951;.
2 +
Daun, H.: Zur Kenntnis des Folch'schen Strandin. Dissertation, Koln, October, 1952.
3 +
Chatagnon, C., and Chatagnon, P.:  Étude Sur Le Strandin De Folch , Bull. Soc. chim. biol. 35:1319-1324, 1953;.
4 +
Klenk, E.:  Über die Ganglioside, eine neue Grupe von Zuckerhaltigen Gehirnlipoiden , Zeitschr. physiol. Chem. 273:76-86, 1942;.
5 +
Folch, J.; Meath, J. A., and Bogoch, S.:  Brain Strandin , Fed. Proc. 15:254, 1956;.
6 +
Blix, G., and Odin, L.:  Isolation of Sialic Acid from Gangliosides , Acta chem. scand. 9:1541-1543, 1955;.
7 +
Blix, G.; Svennerholm, L., and Werner, I.:  The Isolation of Chondrosamine from Gangliosides and from Submaxillary Mucin , Acta. chem. scandinav. 6:358-362, 1952;.
8 +
Folch, J.; Ascoli, I.; Lees, M.; Meath, J. A., and LeBaron, F. N.:  Preparation of Lipide Ex tracts from Brain Tissue , J. Biol. Chem. 191:833-841, 1951;.
9 +
Bogoch, S.:  Degradation of Brain Ganglioside to Glucocerebroside , J. Am. Chem. Soc. 79:3286-3287, 1957;.
10 +
Folch, J.; Lees, M., and Sloane Stanley, G. H.:  A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues , J. Biol. Chem. 226:497-509, 1957;.
11 +
Brante, G.:  Studies on Lipids in the Nervous System with Special Reference to Quantitative Chemical Determination and Topical Distribution , Acta physiol. scandinav. 18:189-217, (suppl. 63) , 1949;.

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References

1 +
Folch, J.; Arsove, S., and Meath, J. A.:  Isolation of Brain Strandin, A New Type of Large Molecule Tissue Component , J. Biol. Chem. 191:819-831, 1951;.
2 +
Daun, H.: Zur Kenntnis des Folch'schen Strandin. Dissertation, Koln, October, 1952.
3 +
Chatagnon, C., and Chatagnon, P.:  Étude Sur Le Strandin De Folch , Bull. Soc. chim. biol. 35:1319-1324, 1953;.
4 +
Klenk, E.:  Über die Ganglioside, eine neue Grupe von Zuckerhaltigen Gehirnlipoiden , Zeitschr. physiol. Chem. 273:76-86, 1942;.
5 +
Folch, J.; Meath, J. A., and Bogoch, S.:  Brain Strandin , Fed. Proc. 15:254, 1956;.
6 +
Blix, G., and Odin, L.:  Isolation of Sialic Acid from Gangliosides , Acta chem. scand. 9:1541-1543, 1955;.
7 +
Blix, G.; Svennerholm, L., and Werner, I.:  The Isolation of Chondrosamine from Gangliosides and from Submaxillary Mucin , Acta. chem. scandinav. 6:358-362, 1952;.
8 +
Folch, J.; Ascoli, I.; Lees, M.; Meath, J. A., and LeBaron, F. N.:  Preparation of Lipide Ex tracts from Brain Tissue , J. Biol. Chem. 191:833-841, 1951;.
9 +
Bogoch, S.:  Degradation of Brain Ganglioside to Glucocerebroside , J. Am. Chem. Soc. 79:3286-3287, 1957;.
10 +
Folch, J.; Lees, M., and Sloane Stanley, G. H.:  A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues , J. Biol. Chem. 226:497-509, 1957;.
11 +
Brante, G.:  Studies on Lipids in the Nervous System with Special Reference to Quantitative Chemical Determination and Topical Distribution , Acta physiol. scandinav. 18:189-217, (suppl. 63) , 1949;.

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