May 1959, Vol 97, No. 5_PART_I >

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Article | May 1959

Kernicterus in Rats with an Inherited Deficiency of Glucuronyl Transferase

LOIS JOHNSON, M.D.; FELICITAS SARMIENTO, M.D.; WILLIAM A. BLANC, M.D.; RICHARD DAY, M.D.

AMA Am J Dis Child. 1959;97(5_PART_I):591-608. doi:10.1001/archpedi.1959.02070010593009.

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This paper describes the occurrence of kernicterus and factors which influence its development in the strain of rats * first studied by Gunn.^22,23 The disease of humans designated in 1903 by Schmorl³⁹ as kernicterus has, in our opinion, not been observed or induced in its entirety in animals. Various workers, however, have demonstrated the toxicity of indirect bilirubin.^{12-15,24,26,44-46} Ernster, Herlin, and Zetterström²¹ have caused localized pigmentation of the brain of the rabbit by treatment with bilirubin and an S-H blocking agent. Other workers^17,19,20 have reported injury of brain tissue in hemolytic anemia of animals, a phenomenon not directly related to the present report, since the rats to be described do not suffer from antibody-antigen disease and have little or no hemolytic

Definition of Kernicterus The following criteria are proposed as defining kernicterus:

Distinctive evidence of central nervous system dysfunction during life in jaundiced subjects

Canary yellow

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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JOHNSON L, SARMIENTO F, BLANC WA, DAY R. Kernicterus in Rats with an Inherited Deficiency of Glucuronyl Transferase. AMA Am J Dis Child. 1959;97(5_PART_I):591-608. doi:10.1001/archpedi.1959.02070010593009.

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