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Familial Addison's Disease:  Case Reports of Two Sisters with Corticoid Deficiency Unassociated with Hypoaldosteronism

THOMAS H. SHEPARD, M.D.; BENJAMIN H. LANDING, M.D.; DAVID G. MASON, M.D.
AMA Am J Dis Child. 1959;97(2):154-162. doi:10.1001/archpedi.1959.02070010156002.
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Although familial Addison's disease has been previously reported, it is usually associated with hypoparathyroidism or with congenital adrenal hyperplasia. Familial Addison's disease by itself is rare. Recent case reports by Whitaker et al.1 and DiGeorge and Paschkis2 have reviewed the subject of hypoparathyroidism and Addison's disease. The Addisonian-like aspect of the familial disease, congenital adrenal hyperplasia, has been reviewed by Iversen,3 Grumbach and Wilkins,4 and Childs et al.5

Reports of familial Addison's disease have been reviewed. Fleming and Miller6 and Croom,7 in 1900 and 1909, respectively, reported family members who were weak and pigmented and who were felt on the basis of clinical observation to have Addison's disease. Rolleston8 mentions the syndrome as occurring in two sisters. Smith and Higgins9 diagnosed the disease in two brothers because of pigmentation and decreased serum sodium. Wakefield and Smith10 reported an excessively pigmented man who at autopsy had adrenal atrophy, possibly secondary to

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