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January 1959, Vol 97, No. 1 >
Article | January 1959

Evaluation of Water-Soluble Hemisuccinate Esters of Hydrocortisone and Prednisolone:  Plasma 17-Hydroxycorticosteroid Concentrations Following Intravenous Administration FREE

JACK MADSEN, M.D.; ALAN K. DONE, M.D.; ROBERT S. ELY, M.D.; VINCENT C. KELLEY, M.D., Ph.D.
[+] Author Affiliations

Submitted for publication May 16, 1958.

Dr. Madsen's present address: Bronx Municipal Hospital Center, New York; Dr. Done's present address: Stanford University School of Medicine, San Francisco; Dr. Ely's present address: University of Arkansas School of Medicine, Little Rock; Dr. Kelley's present address: University of Washington School of Medicine, Seattle.

Doris F. Tippit, Tiona L. Hughes, and Richard B. Young gave technical assistance.

These studies were supported in part by a grant-in-aid from the Upjohn Company, Kalamazoo, Mich.


AMA Am J Dis Child. 1959;97(1):66-71. doi:10.1001/archpedi.1959.02070010068005.
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Comments

The adrenal steroids have assumed a role of major importance in clinical therapy during the past few years. Although clinical application of these compounds has been rapid and extensive, therapy of this type is not without complications and side-effects. As a result, a great deal of research emphasis has been placed upon attempts to synthesize new steroids with enhanced therapeutic effectiveness and with as few as possible deleterious or undesirable properties.

The first major advance in this direction resulted when theΔ1-steroids, prednisone and prednisolone were synthesized.1-4 These compounds are related structurally to cortisone and hydrocortisone, respectively, and differ from the parent steroids by having a double bond in the C-1 position. These Δ1-steroids now have been given extensive trial and have been found to have wide clinical applicability. It has been postulated that the enhanced effectiveness of these compounds is due, in part, to delayed degradation

REFERENCES

1 +
Herzog, H. L.; Nobile, A.; Tolksdorf, S.; Charney, W.; Hershberg, E. B.; Perlman, P. L., and Pechet, M. M.:  New Antiarthritis Steroids , Science 121:176, 1955;.
2 +
Bunin, J. J.; Pechet, M. M., and Bollet, A. J.:  Studies on Metacortandralone and Metacortandracin in Rheumatoid Arthritis , J.A.M.A. 157:311, 1955;.
3 +
Spies, T. D.; Stone, R. E.; Lopez, G. G.; Tellechea, C. M. D.; Toca, R. L.; Reboredo, A., and Suarez, R. M.:  Prednisone and Prednisolone as Therapeutic Agents , J.A.M.A. 159:645, 1955;.
4 +
Thorn, G. W.; Renold, A. E.; Morse, W. I.; Goldfien, A., and Reddy, W. J.:  Highly Potent Adrenal Cortical Steroids: Structure and Biologic Activity , Ann. Int. Med. 43:979, 1955;.
5 +
Ely, R. S.; Done, A. K., and Kelley, V. C.:  Δ-Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations Following Oral and I. V. Administration , Proc. Soc. Exper. Biol. & Med. 91:503, 1956;.
6 +
Nelson, D. H., and Samuels, L. T.:  A Method for the Determination of 17-Hydroxycorticosteroid in Blood: 17-Hydroxycorticosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519, 1952;.
7 +
Eik-Nes, K.; Nelson, D. H., and Samuels, L. T.:  Determination of 17,21-Hydroxycorticosteroids in Plasma , J. Clin. Endocrinol. 13:1280, 1953;.
8 +
Collins, E. J.; Forist, A. A., and Nadolski, E. B.:  Δ1-Hydrocortisone and Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations in the Dog Following Oral and Intravenous Administration , Proc. Soc. Exper. Biol. & Med. 93:369, 1956;.
9 +
Kelley, V. C.; Done, A. K.; Ainger, L. E.; Ely, R. S.; Forist, A. A., and Collins, E. J.:  Evaluation of a New Liquid Dosage Form of Hydrocortisone , J. Pediat. 49:26, 1956;.
10 +
Jakoby, W. B., and Thompkins, G.:  Enzymatic Detoxification Mechanism for Viadril , Science 123:940, 1956;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Herzog, H. L.; Nobile, A.; Tolksdorf, S.; Charney, W.; Hershberg, E. B.; Perlman, P. L., and Pechet, M. M.:  New Antiarthritis Steroids , Science 121:176, 1955;.
2 +
Bunin, J. J.; Pechet, M. M., and Bollet, A. J.:  Studies on Metacortandralone and Metacortandracin in Rheumatoid Arthritis , J.A.M.A. 157:311, 1955;.
3 +
Spies, T. D.; Stone, R. E.; Lopez, G. G.; Tellechea, C. M. D.; Toca, R. L.; Reboredo, A., and Suarez, R. M.:  Prednisone and Prednisolone as Therapeutic Agents , J.A.M.A. 159:645, 1955;.
4 +
Thorn, G. W.; Renold, A. E.; Morse, W. I.; Goldfien, A., and Reddy, W. J.:  Highly Potent Adrenal Cortical Steroids: Structure and Biologic Activity , Ann. Int. Med. 43:979, 1955;.
5 +
Ely, R. S.; Done, A. K., and Kelley, V. C.:  Δ-Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations Following Oral and I. V. Administration , Proc. Soc. Exper. Biol. & Med. 91:503, 1956;.
6 +
Nelson, D. H., and Samuels, L. T.:  A Method for the Determination of 17-Hydroxycorticosteroid in Blood: 17-Hydroxycorticosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519, 1952;.
7 +
Eik-Nes, K.; Nelson, D. H., and Samuels, L. T.:  Determination of 17,21-Hydroxycorticosteroids in Plasma , J. Clin. Endocrinol. 13:1280, 1953;.
8 +
Collins, E. J.; Forist, A. A., and Nadolski, E. B.:  Δ1-Hydrocortisone and Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations in the Dog Following Oral and Intravenous Administration , Proc. Soc. Exper. Biol. & Med. 93:369, 1956;.
9 +
Kelley, V. C.; Done, A. K.; Ainger, L. E.; Ely, R. S.; Forist, A. A., and Collins, E. J.:  Evaluation of a New Liquid Dosage Form of Hydrocortisone , J. Pediat. 49:26, 1956;.
10 +
Jakoby, W. B., and Thompkins, G.:  Enzymatic Detoxification Mechanism for Viadril , Science 123:940, 1956;.

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