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Idiopathic Hypercalcemia of Infancy FREE

C. HARRISON SNYDER, M.D.
[+] Author Affiliations

Submitted for publication March 13, 1958.


AMA Am J Dis Child. 1958;96(3):376-380. doi:10.1001/archpedi.1958.02060060378016.
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The disease called "idiopathic hypercalcemia of infancy" has received considerable attention in recent European pediatric literature. Butler1 and Fanconi2,3 reported the first two cases in 1951. In 1953 the syndrome was first clearly delineated by Lightwood and Stapleton.4 Since then, many cases have been seen in Great Britain,5-12 where, in fact, the condition appears to be comparatively common. It is reported that in Dundee, Scotland, 5% of all babies entering hospitals between the ages of 6 and 12 months were found to have this disorder.8

By contrast, the disease has been almost unknown in the United States. To date only five cases have been reported in this country.13-15 Doubtless, however, there have been more cases that have been unrecognized, and it behooves the American pediatrician to acquaint himself with the clinical features of the disease. This is especially true because early diagnosis and treatment

REFERENCES

Butler, N. R.:  Generalized Retardation, with Renal Impairment, Hypercalcemia, and Osteosclerosis of the Skull , Proc. Roy. Soc. Med. 44:296-297 ( (April) ) 1951;.
Fanconi, G.:  Über chronische Störungen des Calcium- und Phosphatstoffwechsels im Kindesalter , Schweiz. med. Wchnschr. 81:908-913 ( (Sept. 22) ) 1951;.
Fanconi, G.:  Chronische Hypercalcämie, kombiniert mit Osteosklerose, Hyperazotämie, Minderwuchs, und Kongenitalen Misabildungen , Helvet. paediat. acta 7:314-349 ( (Aug.) ) 1952;.
Lightwood, R., and Stapleton, T.:  Idiopathic Hypercalcemia in Infants , Lancet 2:255-256 ( (Aug. 1) ) 1953;.
Creevy, R. D. G., and Neill, D. W.:  Idiopathic Hypercalcemia in Infants with Failure to Thrive , Lancet 2:110-114 ( (July 17) ) 1954;.
Dawson, I. M. P.; Craig, W. S., and Perera, F. J. C.:  Idiopathic Hypercalcemia in an Infant , Arch. Dis. Childhood 29:475-482 ( (Dec.) ) 1954;.
Schlesinger, B. E.; Butler, N. R., and Black, J. A.:  Severe Type of Infantile Hypercalcemia , Brit. M. J. 1:127-134 ( (Jan. 21) ) 1956;.
Morgan, H. G.; Mitchell, R. G.; Stowers, J. M., and Thomson, J.:  Metabolic Studies on 2 Infants with Idiopathic Hypercalcaemia , Lancet 1:925-931 ( (June 16) ) 1956;.
Stapleton, T.; MacDonald, W. B., and Lightwood, R.:  The Management of Idiopathic Hypercalcemia in Infancy , Lancet 1:932-934 ( (June 16) ) 1956;.
Forfar, J. O.; Balf, C. L.; Maxwell, G. M., and Tompsett, S. L.:  Idiopathic Hypercalcemia of Infancy: Clinical and Metabolic Studies with Special Reference to the Aetiological Role of Vitamin D , Lancet 1:981-988 ( (June 23) ) 1956;.
Rhaney, K., and Mitchell, R. G.:  Idiopathic Hypercalcemia of Infants , Lancet 1:1028-1032 ( (June 30) ) 1956;.
 Idiopathic Hypercalcemia in Infancy , Editorials, Lancet 1:1052-1053 ( (June 30) ) 1956;.
Daeschner, G. L., and Daeschner, C. W.:  Severe Idiopathic Hypercalcemia of Infancy , Pediatrics 19:362-371 ( (March) ) 1957;.
 Clinical Pathological Conference , J. Pediat. 51:461-473 ( (Oct.) ) 1957;.
Bongiovanni, A. M.; Eberlein, W. R., and Jones, I. T.:  Idiopathic Hypercalcemia of Infancy, with Failure to Thrive , New England J. Med. 257:951-958 ( (Nov. 14) ) 1957;.
Connor, T. B., et al.:  Use of Cortisone and ACTH in Hypercalcemic States , J. Clin. Endocrinol. 16:945 ( (July) ) 1956;.
Vagelos, P. R., and Henneman, P. H.:  Effect of Sodium Phytate on the Hypercalcemia of Acute Quadriplegia Due to Poliomyelitis , New England J. Med. 256:773-776 ( (April 25) ) 1956;.
Cogan, D. C., and Henneman, P. H.:  Diffuse Calcification of the Cornea in Hypercalcemia , New England J. Med. 257:451-453 ( (Sept. 5) ) 1957;.

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References

Butler, N. R.:  Generalized Retardation, with Renal Impairment, Hypercalcemia, and Osteosclerosis of the Skull , Proc. Roy. Soc. Med. 44:296-297 ( (April) ) 1951;.
Fanconi, G.:  Über chronische Störungen des Calcium- und Phosphatstoffwechsels im Kindesalter , Schweiz. med. Wchnschr. 81:908-913 ( (Sept. 22) ) 1951;.
Fanconi, G.:  Chronische Hypercalcämie, kombiniert mit Osteosklerose, Hyperazotämie, Minderwuchs, und Kongenitalen Misabildungen , Helvet. paediat. acta 7:314-349 ( (Aug.) ) 1952;.
Lightwood, R., and Stapleton, T.:  Idiopathic Hypercalcemia in Infants , Lancet 2:255-256 ( (Aug. 1) ) 1953;.
Creevy, R. D. G., and Neill, D. W.:  Idiopathic Hypercalcemia in Infants with Failure to Thrive , Lancet 2:110-114 ( (July 17) ) 1954;.
Dawson, I. M. P.; Craig, W. S., and Perera, F. J. C.:  Idiopathic Hypercalcemia in an Infant , Arch. Dis. Childhood 29:475-482 ( (Dec.) ) 1954;.
Schlesinger, B. E.; Butler, N. R., and Black, J. A.:  Severe Type of Infantile Hypercalcemia , Brit. M. J. 1:127-134 ( (Jan. 21) ) 1956;.
Morgan, H. G.; Mitchell, R. G.; Stowers, J. M., and Thomson, J.:  Metabolic Studies on 2 Infants with Idiopathic Hypercalcaemia , Lancet 1:925-931 ( (June 16) ) 1956;.
Stapleton, T.; MacDonald, W. B., and Lightwood, R.:  The Management of Idiopathic Hypercalcemia in Infancy , Lancet 1:932-934 ( (June 16) ) 1956;.
Forfar, J. O.; Balf, C. L.; Maxwell, G. M., and Tompsett, S. L.:  Idiopathic Hypercalcemia of Infancy: Clinical and Metabolic Studies with Special Reference to the Aetiological Role of Vitamin D , Lancet 1:981-988 ( (June 23) ) 1956;.
Rhaney, K., and Mitchell, R. G.:  Idiopathic Hypercalcemia of Infants , Lancet 1:1028-1032 ( (June 30) ) 1956;.
 Idiopathic Hypercalcemia in Infancy , Editorials, Lancet 1:1052-1053 ( (June 30) ) 1956;.
Daeschner, G. L., and Daeschner, C. W.:  Severe Idiopathic Hypercalcemia of Infancy , Pediatrics 19:362-371 ( (March) ) 1957;.
 Clinical Pathological Conference , J. Pediat. 51:461-473 ( (Oct.) ) 1957;.
Bongiovanni, A. M.; Eberlein, W. R., and Jones, I. T.:  Idiopathic Hypercalcemia of Infancy, with Failure to Thrive , New England J. Med. 257:951-958 ( (Nov. 14) ) 1957;.
Connor, T. B., et al.:  Use of Cortisone and ACTH in Hypercalcemic States , J. Clin. Endocrinol. 16:945 ( (July) ) 1956;.
Vagelos, P. R., and Henneman, P. H.:  Effect of Sodium Phytate on the Hypercalcemia of Acute Quadriplegia Due to Poliomyelitis , New England J. Med. 256:773-776 ( (April 25) ) 1956;.
Cogan, D. C., and Henneman, P. H.:  Diffuse Calcification of the Cornea in Hypercalcemia , New England J. Med. 257:451-453 ( (Sept. 5) ) 1957;.

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