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September 1958, Vol 96, No. 3 >
Article | September 1958

Prognosis in Neuroblastoma of Childhood FREE

WATARU W. SUTOW, M.D.
[+] Author Affiliations

Submitted for publication March 28, 1958.


AMA Am J Dis Child. 1958;96(3):299-305. doi:10.1001/archpedi.1958.02060060301008.
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References
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The change in the medical attitude toward prognosis in neuroblastoma of childhood received its major impetus from the reports of Farber1 and of Gross.2 Subsequent publications from other centers3-5 have amply confirmed the observation that there is a definite and significant long-term survival rate among the children with neuroblastoma. The magnitude of this survival rate appears to be influenced by several factors, among which age of the patient, presence of metastases, and degree of malignancy have been suggested.

The clinical experience at The University of Texas M. D. Anderson Hospital and Tumor Institute (MDAH), however, during the period from 1951 through 1957 disclosed what appeared to be consistently unsatisfactory end-results in 15 children with neuroblastoma (Table 1). Eleven of the fifteen were dead within nine months. Only one child was living and apparently free of disease four years after

diagnosis. Of three additional children who were still

REFERENCES

1 +
Farber, S.:  Neuroblastoma , Am. J. Dis. Child. 60:749, 1940;.
2 +
Gross, E.: Surgery of Infancy and Childhood , Philadelphia, W. B. Saunders Company, 1953;, p. 606.
3 +
Beck, S. M., Jr., and Howard, P. J.:  Neuroblastoma: Review of the Literature and Report of 6-Year Cure by Roentgen Therapy , A. M. A. Am. J. Dis. Child. 82:325, 1951;.
4 +
Phillips, R.:  Neuroblastoma , Ann. Roy. Coll. Surgeons 12:29, 1953;.
5 +
Horn, R. C., Jr.; Koop, C. E., and Kiesewetter, W. B.:  Neuroblastoma in Childhood: Clinicopathologic Study of 44 Cases , Lab. Invest. 5:106, 1956;.
6 +
Ackerman, L. V., and Taylor, F. H.:  Neurogenous Tumors Within the Thorax: A Clinicopathological Evaluation of 48 Cases , Cancer 4: 669, 1951;.
7 +
Charache, H.:  Tumors in Children , New York J. Med. 54:1775, 1954;.
8 +
Oberkircher, O. J.; Staubitz, W. J., and Parmenter, F. J.:  A Clinical Study of Neuroblastoma , J. Pediat. 43:177, 1953;.
9 +
Pack, G. T.; Horning, E. D., and Ariel, I. M.:  Neuroblastoma (Sympathicoblastoma) with an Analysis of 14 Cases and a Survey of the Literature , J. Neuropath. & Exper. Neurol. 11: 235, 1952;.
10 +
Poore, T. N.; Dockerty, M. B.; Kennedy, R. L. J., and Walters, W.:  Symposium on Surgical Aspects of the Cancer Problem: Abdominal Neuroblastomas , S. Clin. North America 31:1121, 1951;.
11 +
Reiquam, C. W.; Beatty, E. C., Jr., and Allen, R. P.:  Neuroblastomas in Infancy and Childhood: A Review of 10 Years' Experience , A. M. A. J. Dis. Child. 91:588, 1956;.
12 +
Seaman, W. B., and Eagleton, M. D.:  Radiation Therapy of Neuroblastoma , Radiology 68:1, 1957;.
13 +
Snyder, W. H., Jr.; Kruse, C. A.; Greaney, E. M., and Chaffin, L.:  Retroperitoneal Tumors in Infants and Children: Report of 88 Cases , A. M. A. Arch. Surg. 63:26, 1951;.
14 +
Stowens, D.:  Neuroblastoma and Related Tumors , A. M. A. Arch. Path. 63:451, 1957;.
15 +
Uhlmann, E. M., and von Essen, C.:  Neuroblastoma (Neuroblastoma Sympatheticum) , Pediatrics 15:402, 1955;.
16 +
Wittenborg, M. H.:  Roentgen Therapy in Neuroblastoma: A Review of 73 Cases , Radiology 54:679, 1950;.
17 +
Franklin, J. E.:  Analysis of Cancer in Infancy and Childhood , New York J. Med. 53: 1659, 1953;.
18 +
Farber, S.; Toch, R.; Sears, E. M., and Pinkel, D.:  Advances in Chemotherapy of Cancer in Man , Advances Cancer Res. 4:2, 1956;.
19 +
The Treatment of Neuroblastoma with Vitamin B12 , British Empire Cancer Campaign Report, London, 1954;, p. 199.
20 +
Collins, V. P.; Loeffler, R. K., and Tivey, H.:  Observations on Growth Rates of Human Tumors , Am. J. Roentgenol. 76:988, 1956;.
21 +
Stewart, F. W.: Factors Influencing Curability of Cancer, in Third National Cancer Conference Proceedings, Philadelphia, J. B. Lippincott Company, 1957, p. 62.
22 +
Shimkin, M. B.:  Natural History of Neoplastic Disease , cited by Homburger, F.: The Biologic Basis of Cancer Management , New York, Paul B. Hoeber, Inc. (medical book department of Harper & Brothers), 1957;, p. 155.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Farber, S.:  Neuroblastoma , Am. J. Dis. Child. 60:749, 1940;.
2 +
Gross, E.: Surgery of Infancy and Childhood , Philadelphia, W. B. Saunders Company, 1953;, p. 606.
3 +
Beck, S. M., Jr., and Howard, P. J.:  Neuroblastoma: Review of the Literature and Report of 6-Year Cure by Roentgen Therapy , A. M. A. Am. J. Dis. Child. 82:325, 1951;.
4 +
Phillips, R.:  Neuroblastoma , Ann. Roy. Coll. Surgeons 12:29, 1953;.
5 +
Horn, R. C., Jr.; Koop, C. E., and Kiesewetter, W. B.:  Neuroblastoma in Childhood: Clinicopathologic Study of 44 Cases , Lab. Invest. 5:106, 1956;.
6 +
Ackerman, L. V., and Taylor, F. H.:  Neurogenous Tumors Within the Thorax: A Clinicopathological Evaluation of 48 Cases , Cancer 4: 669, 1951;.
7 +
Charache, H.:  Tumors in Children , New York J. Med. 54:1775, 1954;.
8 +
Oberkircher, O. J.; Staubitz, W. J., and Parmenter, F. J.:  A Clinical Study of Neuroblastoma , J. Pediat. 43:177, 1953;.
9 +
Pack, G. T.; Horning, E. D., and Ariel, I. M.:  Neuroblastoma (Sympathicoblastoma) with an Analysis of 14 Cases and a Survey of the Literature , J. Neuropath. & Exper. Neurol. 11: 235, 1952;.
10 +
Poore, T. N.; Dockerty, M. B.; Kennedy, R. L. J., and Walters, W.:  Symposium on Surgical Aspects of the Cancer Problem: Abdominal Neuroblastomas , S. Clin. North America 31:1121, 1951;.
11 +
Reiquam, C. W.; Beatty, E. C., Jr., and Allen, R. P.:  Neuroblastomas in Infancy and Childhood: A Review of 10 Years' Experience , A. M. A. J. Dis. Child. 91:588, 1956;.
12 +
Seaman, W. B., and Eagleton, M. D.:  Radiation Therapy of Neuroblastoma , Radiology 68:1, 1957;.
13 +
Snyder, W. H., Jr.; Kruse, C. A.; Greaney, E. M., and Chaffin, L.:  Retroperitoneal Tumors in Infants and Children: Report of 88 Cases , A. M. A. Arch. Surg. 63:26, 1951;.
14 +
Stowens, D.:  Neuroblastoma and Related Tumors , A. M. A. Arch. Path. 63:451, 1957;.
15 +
Uhlmann, E. M., and von Essen, C.:  Neuroblastoma (Neuroblastoma Sympatheticum) , Pediatrics 15:402, 1955;.
16 +
Wittenborg, M. H.:  Roentgen Therapy in Neuroblastoma: A Review of 73 Cases , Radiology 54:679, 1950;.
17 +
Franklin, J. E.:  Analysis of Cancer in Infancy and Childhood , New York J. Med. 53: 1659, 1953;.
18 +
Farber, S.; Toch, R.; Sears, E. M., and Pinkel, D.:  Advances in Chemotherapy of Cancer in Man , Advances Cancer Res. 4:2, 1956;.
19 +
The Treatment of Neuroblastoma with Vitamin B12 , British Empire Cancer Campaign Report, London, 1954;, p. 199.
20 +
Collins, V. P.; Loeffler, R. K., and Tivey, H.:  Observations on Growth Rates of Human Tumors , Am. J. Roentgenol. 76:988, 1956;.
21 +
Stewart, F. W.: Factors Influencing Curability of Cancer, in Third National Cancer Conference Proceedings, Philadelphia, J. B. Lippincott Company, 1957, p. 62.
22 +
Shimkin, M. B.:  Natural History of Neoplastic Disease , cited by Homburger, F.: The Biologic Basis of Cancer Management , New York, Paul B. Hoeber, Inc. (medical book department of Harper & Brothers), 1957;, p. 155.

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