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Salt-Losing Nephritis

AMA Am J Dis Child. 1958;96(2):191-196. doi:10.1001/archpedi.1958.02060060193010.
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Salt-losing nephritis is one of many clinical situations involving electrolyte disturbance in renal disease. This type of nephropathy is characterized by hyponatremia and hypochloremia, lassitude, thirst, polyuria, azotemia, and circulatory collapse. The syndrome was first described by Thorn, Koepf, and Clinton1 in 1944. Since then, 15 additional cases have been reported2-11 which satisfy the criteria of Levere and Wesson9 for salt-losing nephropathies.

The purpose of this report is to present the first case of salt-losing nephritis in the pediatric age group and to outline the therapeutic regimen based on the pathophysiology of the syndrome.

Report of Case  A 12-year-old white boy was admitted to Montefiore Hospital on Aug. 10, 1956, for the third time because of expectoration of bloody material. The first two admissions were on the private service on April 7, 1956, and July 11, 1956, for anemia.He was transfused on each admission but received


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