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Butanol-Extractable Iodine Values in the Offspring of Diabetic Women

HENRY K. SILVER, M.D.
AMA Am J Dis Child. 1958;96(2):144-147. doi:10.1001/archpedi.1958.02060060146003.
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Infants born of women with diabetes mellitus often present serious problems and have an increased morbidity and mortality. Studies of these infants and of the mothers during their pregnancies have failed to reveal the pathogenesis of the phenomena that occur among the infants. It has been suggested that such changes are related to a disturbance of maternal sex harmones, but the exact alterations or specific manner in which they affect the infant have not been determined. The present report is concerned with studies of butanol-extractable iodine (BEI) values in the serum of infants born of diabetic women who did not receive any sex-hormone therapy during pregnancy. The data, although limited and of a preliminary nature, are offered at this time to enable others who have access to more clinical material to follow up these studies.

Method  Assays for serum BEI were performed on blood obtained immediately after birth from the

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