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Gynecomastia and Pseudoprecocious Puberty Following Diethylstilbestrol Exposure

AMA Am J Dis Child. 1958;95(6):637-639. doi:10.1001/archpedi.1958.02060050641008.
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The purpose of this paper is to report the occurrence of gynecomastia in a 3-year-old boy and pseudoprecocious puberty in his 23-month-old sister following exposure to diethylstilbestrol (stilbestrol).

Report of Cases  A 38/12-year-old white boy was seen in the Yale Private Diagnostic Clinic on Oct. 22, 1956, because of bilateral breast enlargement present since January, 1956. There were no other complaints. Growth and development had otherwise been normal. The child was in the 50th percentile for height and 90th percentile for weight. As illustrated in Figure 1, the breasts were enlarged to a moderate degree. Freely moveable, circumscribed masses of glandular tissue about 2 cm. in diameter were palpable under the areolae. The nipples, areolae, and linea alba were deeply pigmented. A scanty amount of downy pubic hair was present. Axillary hair was absent. Neurologic and funduscopic examinations were negative. The testes were of normal size. No palpable testicular masses


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